Effectiveness and safety of Ojeok-san plus Saengmaek-san for chronic cough
- Conditions
- Diseases of th respiratory system
- Registration Number
- KCT0003115
- Lead Sponsor
- Kyung Hee University Oriental Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 30
1) Only 19 years old and under 70 years old
2) Persons who have continued coughing for more than 8 weeks
3) who have been diagnosed with reflux esophagitis within the last 1 year
4) In case of patient,
1) Those with abnormal findings that could cause cough as a result of chest x-ray
2) Those with abnormal findings in lung function tests
3) Those with evidence of coughing on nasal endoscopy
4) Those who have been diagnosed with acute respiratory disease including upper respiratory tract within the last 1 month
5) Those who have been diagnosed with chronic respiratory diseases (chronic obstructive pulmonary disease, bronchial asthma, bronchiectasis, interstitial pulmonary disease and other chronic respiratory diseases) within the last 2 years
6) who have been diagnosed gastroesophageal reflux disease of LA grade C or higher within the last 1 year
7) Patients who present with symptoms that can predict the malignant disease of the gastrointestinal tract (swallowing, severe dysphagia, bleeding, weight loss, anemia, stool, etc.)
8) Patients who had previously undergone surgical or endoscopic anti-reflux treatment
9) Patient with Hubiru syndrome
10) Patients with active infection requiring systemic antibiotic treatment
11) Patients with blood clotting disorder
12) Those who smoke more than 20 packs (400 packs)
13) Those who have been taking or have taken an angiotensin-converting-enzyme inhibitor within the last 4 months
14) Those who have been taking chronotherapy, steroids, anti-leukotrienes, anticholinergics, long-acting ß2 agonists, and any herbal medicines within the last 2 weeks
15) Those taking antihistamines within the last 2 weeks
16) Those who have taken proton pump inhibitors, histamine receptor antagonists, mucosal protective agents, gastrointestinal motility promoters, antacids, antidepressants, anxiolytics, and lower esophageal sphincter agonists for the treatment of gastroesophageal reflux disease symptoms within the last 2 weeks
17) Allergy or sensitizer to test drug / placebo
18) Those with a low birth weight below 18.5 on the BMI
19) Blood test results showed that AST and ALT were 2 times higher than the normal upper limit and Creatinine was 1.2 times higher than the normal upper limit
20) Those with a mean cough diary of 2 or less during the run-in-period period (7 days)
21) who recorded less than 10 cough diaries during the run-in-period period (7 days)
22) Those who had malignant tumors such as lung cancer or esophageal cancer within 5 years
23) Excessive drinking
24) Those who are pregnant or lactating
25) Those who did not consent to contraception during the clinical trial
26) Patients who participated in clinical trials for the same disease within the past 3 months
27) Those who are not eligible to take part in this trial at the discretion of the investigator
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method