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临床试验/NCT04567641
NCT04567641已完成不适用

Impact of Early Enteral & Parenteral Nutrition on Post-operative Outcome After Abdominal Surgery

Cairo University0 个研究点目标入组 80 人开始时间: 2017年1月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
80
主要终点
duration of mechanical ventilation.

研究概览

简要总结

Introduction: Nutritional support is a vital therapy of most surgical patients. Early initiation via the enteral route has a significant effect on postoperative recovery. The prognostic role of CRP and albumin can be explained by their abilities to reflect inflammation in the acute phase in critical settings and assess the nutritional status of critically ill patients, respectively. This indicates the prognostic value of the CRP/ALB ratio in postoperative patients admitted to the ICU.

Aim of work: Determine the effect of early enteral & parenteral nutrition on ICU outcome & nutritional status in postoperative abdominal surgical patients and investigate the effect of enteral & parenteral nutrition on CRP/albumin ratio as an inflammatory marker & its correlation with SOFA score.

Methods: A prospective cohort non randomized study included 80 postoperative abdominal surgical patients at Critical Care Department, Cairo University over one year duration. Forty patients (50%) received enteral nutrition 6 hours after surgical procedures and 40 patients (50%) received parenteral nutrition 6 hours after surgical procedures. Nutritional status and inflammatory markers were screened. All patients were followed up during the ICU stay & up to 3 months. SOFA scoring was done every 48 hours.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • postoperative abdominal surgical patients at Critical Care Department, Cairo University over one year duration.
  • age between 18-80 years

排除标准

  • renal failure
  • liver failure
  • extensive burns
  • hemodynamic instability.

结局指标

主要结局

duration of mechanical ventilation.

时间窗: 7 days

measurement of days of mechanical ventilation

Gastro-intestinal tolerance: vomitting or diarrhea

时间窗: 7 days

number of participants who develop nausea, vomitting or diarrhea

Refeeding syndrome; hypokalemia and hypophosphatemia

时间窗: 7 days

number of participants who develop hypokalemia and hypophosphatemia

length of ICU stay

时间窗: 7 days

measurement of days of ICU stay

次要结局

  • 3 months survival after discharge .(90 days)
  • re-admission within 30 days(30 days)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Mostafa Farouk

clinical professor

Cairo University

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