The pharmacokinetics of nimodipine, intravenous and orally, in patients with subarachnoidal haemorrhage admitted in intensive care
Completed
- Conditions
- Subarachnoidal haemorrhageCirculatory SystemCerebrovascular diseases
- Registration Number
- ISRCTN45381163
- Lead Sponsor
- VU University Medical Centre (VUMC) (The Netherlands)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
1. All patients admitted to the Intensive Care Unit (ICU) with subarachnoidal bleeding/haemorrhage (SAB), treated according to our SAB-protocol
2. Adults aged 18 to 70 years old
Exclusion Criteria
1. Pregnancy
2. Expected mortality in less than 24 hours
3. Severe hepatic function disorders
4. Use of medication with known interaction in relation to nimodipine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Pharmacokinetics of nimodipine in this specific group of patients<br>2. Variability of bio-availability of orally administred nimodipine
- Secondary Outcome Measures
Name Time Method o secondary outcome measures