Develop a Novel Occupational Training Program for Schizophrenia Patients Based on Virtual Reality Techniques

Not Applicable

Recruiting

• Conditions: Schizophrenia; Cognitive Impairment
• Interventions: Behavioral: VR-assisted occupational training

• Registration Number: NCT05830903
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

Establish a novel vocational training program and test its validity in a pilot study.

Detailed Description

40 schizophrenia patients will be recruited to join the virtual reality based vocational training program, the training effect will be compared by interview skills and problem solving before and after the training.

Study Timeline

• Study First Submitted: 2019-07-04
• Study Start: 2020-01-01
• Status Verified: 2023-04
• Study First Submitted QC: 2023-04-13
• Study First Posted: 2023-04-26
• Last Update Submitted: 2023-05-04
• Last Update Posted: 2023-05-06
• Primary Completion: 2023-12-31
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Having a diagnosis of schizophrenia based on the Diagnostic and Statistical Manual of Mental Disorders -5th version
• Aged between 20 and 55 years.
• Motivated to have a job.
• Having a full-scale IQ > 70 on the Wechsler Adult Intelligence Scale-version IV.
• Having a PANSS positive scale < 70, indicating a stable condition during the illness course.

Exclusion Criteria

• Comorbid with other major psychiatric disorders (i.e., bipolar disorders) or neurological diseases.
• Substance abuse within one year.
• Visual impairment and/or hearing impairment that would preclude participation in the VR-based training program.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Mild ED/Severe NS	VR-assisted occupational training	10 patients with mild or none executive function impairment and severe or moderate negative symptoms.
Mild ED/NS	VR-assisted occupational training	10 patients with mild or none executive function impairment and mild or none negative symptoms.
Severe ED/Mild NS	VR-assisted occupational training	10 patients with severe or moderate executive function impairment and mild or none negative symptoms.
Severe ED/NS	VR-assisted occupational training	10 patients with severe or moderate executive function impairment and severe or moderate negative symptoms.

Primary Outcome Measures

Name	Time	Method
clinical ratings of schizophrenia symptoms	8 weeks	The Positive and Negative Syndrome Scale (PANSS) is a 30-item rating scale completed by trained research staff. Scores for positive, negative, cognitive disorganization, emotional discomfort, and hostility/excitement symptoms were derived from factor-derived scoring published.; \* There are 30 different symptoms rated from 1 to 7 (total score of 210). Higher the score, worse the symptoms
vocational skills	8 weeks	Job interview role-play performance will be scored across nine domains: conveying oneself as a hard worker, sounding easy to work with, conveying that one behaves professionally, negotiation skills (requesting one day off), sharing things in a positive way, sounding honest, sounding interested in the position, comfort level, and establishing rapport
global improvement	8 weeks	Clinical Global Impression Improvement scale (CGI-I) rating scales are commonly used measures of symptom severity, treatment response and the efficacy in treatment studies of patients with mental disorders. It is a 7-point scale that require clinician to assess how much the patient's illness has improved or worsened relative to baseline. "1" meaning very much improved, "7" meaning very much worsen.

Trial Locations

Locations (1)

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan