acetyl cysteine: could it be an effective adjuvant therapy in infertile women undergoing intra-cytoplasmic sperm injection (ICSI) in achieving more pregnancy?
Completed
- Conditions
- InfertilityReproductive Health and Childbirth - Fertility including in vitro fertilisation
- Registration Number
- ACTRN12609000274279
- Lead Sponsor
- Eman, A. Elgindy
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 76
Inclusion Criteria
Women undergoing ICSI cycles for male infertility
Exclusion Criteria
Age > 37 years, body mass index < 18 or > 29 kg/m2, cycles < 24 days or > 35 days, single ovary, day 3 follicle stimulating hormone 9.5 milli international unit/ml or more, basal total antral follicle count 6 or less, cases refused to sign a consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical pregnancy rate diagnosed by measuring serum human chorionic gonadotropin hormone and ultrasound scan[3 weeks after a (+)ve serum hCG]
- Secondary Outcome Measures
Name Time Method Granulosa cell apoptosis using Annexin V-Propidium iodide Detection Flow Cytometry[within 1 hour of follicular aspiration];Fertilization rate by inspecting the number of oocytes with 2 pronuclei and 2 polar bodies under dissecting microscope[16-18 hours after ICSI];Grade I embryo (equal blastomeres without fragmentation under the microscope)[At the time of embryo transfer (ET)];Ongoing pregnancy rate through ultrasound scan[12 weeks after a (+)ve serum hCG test]