Clinical Significance of Marginal Acute Inflammation for Stage II Colon Cancer

Completed

• Conditions: Colon Cancer; Inflammation
• Interventions: Diagnostic Test: MAI detection

• Registration Number: NCT06135558
• Lead Sponsor: Sun Yat-sen University

Brief Summary

Marginal acute inflammation would make reporting the serosal involvement of tumors controversial. We aimed to investigate the clinical significance and explore the prognostic value of MAI for stage II localized colon cancer.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-01-30
• Primary Completion: 2022-12-30
• Study Completion: 2023-10-30
• Status Verified: 2023-11
• Study First Submitted: 2023-11-11
• Study First Submitted QC: 2023-11-11
• Last Update Submitted: 2023-11-11
• Study First Posted: 2023-11-18
• Last Update Posted: 2023-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1167

Inclusion Criteria

• (1) colon cancer patients with the preoperative staging of stage I-III who lacked distant metastasis; (2) patients who underwent radical resection, with postoperative pathology confirmed as pT3-4N0M0; and (3) complete follow-up information

Exclusion Criteria

• (1) patients who received neo-adjuvant therapy; (2) patients with multiple primary colorectal cancer; and (3) patients with a history of malignant tumors

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
MAI	MAI detection	patient with marginal acute inflammation
T4	MAI detection	patient staged T4 without marginal acute inflammation
T3	MAI detection	patient staged T3 without marginal acute inflammation

Primary Outcome Measures

Name	Time	Method
DFS	5 year	disease free survival