A Multicenter Retrospective Study in China: the Factors Influencing the Success of Redo Surgery and Anal Function for Anastomosis Failure or Local Tumor Recurrence
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 143
- 主要终点
- Whether postoperative patients with rectal cancer can restore intestinal continuity, that is, defecate through the anus
研究概览
简要总结
To analyze the influencing factors of the success of redo surgery due to anastomotic fistula or anastomotic recurrence after rectal cancer surgery and to evaluate the anal function of patients
详细描述
Redo surgery is a critical salvage strategy for anastomotic complications or local recurrence following rectal cancer resection. Despite technical feasibility, functional outcomes remain suboptimal. This study evaluated intestinal continuity restoration and anal function recovery after redo surgery, alongside prognostic factors influencing outcomes. A retrospective multicenter study analyzed 143 patients undergoing redo surgery (2015-2023) for anastomotic failure or local recurrence. Primary endpoints included anatomical restoration of intestinal continuity, while secondary endpoints assessed functional outcomes using the LARS score.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Prior curative resection for primary colorectal adenocarcinoma.
- •Subsequent reoperation for anastomotic failure or locoregional recurrence.
- •Absence of absolute contraindications to reoperative surgery.
排除标准
- •Primary tumors located proximal to the sigmoid colon.
- •Radiologically confirmed distant metastases.
- •Presence of a permanent stoma at the time of questionnaire administration.
- •Insufficient literacy or cognitive function to complete study-related -questionnaires.
结局指标
主要结局
Whether postoperative patients with rectal cancer can restore intestinal continuity, that is, defecate through the anus
时间窗: During the follow-up period, at least two years after rectal cancer surgery
次要结局
- Low Anterior Rectal Syndrome (LARS) Score of patients restoring intestinal continuity(During the follow-up period, at least one year has passed since the intestinal continuity was restored)