Effectiveness of Vitamin D in Primary Dysmenorrhoea
- Conditions
- Primary Dysmenorrhoea
- Interventions
- Registration Number
- NCT02441530
- Lead Sponsor
- Bezmialem Vakif University
- Brief Summary
Vitamin D in the treatment of primary dysmenorrhoea. Design:Randomised controlled trial. Setting:In a university hospital. Population: 142 women aged 16-35 years. Methods: Patients were treated with 667 unit of vitamin D once a day, 200 unit of vitamin E once a day or 400 mg ibuprofen twice a day,2 days before the date of menstruation and continued through the first 3 days, for 2 months. Main outcome measures: Pain score. Results: Mean VAS of vitamin D group was 4,91, was 6,54 in the vitamin E group and was 4,02 in the ibuprofen group Conclusion:Vitamin D and vitamin E are effective in relieving the pain,but the effect of vitamin D are more prominent
- Detailed Description
An excessive uterine production of prostaglandins is the pathogenic trigger of dysmenorrhoea. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the currently accepted drugs for the management of this disorder. The capacity for synthesizing vitamin D and the presence of vitamin D receptor in human cycling endometrium have also been demonstrated. Because vitamin D reduces the synthesis of prostaglandins, a beneficial effect of vitamin D for the uterus is possible.Vitamin E inhibits the release of arachidonic acid and the conversion of arachidonic acid to prostaglandin via an action on the enzymes phospholipase A2 and cyclooxygenase.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 143
- Women had regular menstrual cycles lasted 21 to 35 days, with menstruation lasting 3 to 7 days;
- Women had to be in good health and taking no medications including calcium, magnesium, vitamin D and oral contraceptives.
- Women had not a previous history of gynaecological disease, and a normal pelvic examination were eligible.
- Previous and current use of intrauterine contraceptive devices within the 6 months to enrollment was not permitted
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description vitamin E Vitamin E 200 unit of vitamin E once a day ,two days before the expected date of menstruation and continued through the first three days of bleeding. vitamin D Vitamin D 667 unit of vitamin D once a day ,two days before the expected date of menstruation and continued through the first three days of bleeding. ibuprofen Ibuprofen 400 mg ibuprofen twice a day, two days before the expected date of menstruation and continued through the first three days of bleeding.
- Primary Outcome Measures
Name Time Method pain score ,make a mark on a 10-cm visual analog scale (VAS) 2 months
- Secondary Outcome Measures
Name Time Method