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临床试验/NCT02672930
NCT02672930已完成不适用

How Much Reliable iv Calcium for the Treatment of Hyperkalemia?

Haseki Training and Research Hospital1 个研究点 分布在 1 个国家目标入组 111 人开始时间: 2015年7月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
111
试验地点
1
主要终点
ECG changes after the calcium infusion

研究概览

简要总结

Hyperkalemia is a common problem in the emergency services and one of the life threatening metabolic emergencies. Calcium, insulin, beta adrenoceptor agonists, bicarbonate, diuretics, sodium polystyrene sulfonate and lastly dialysis are advised in treatment. Especially, avoiding evolution of serious arrythmias and iv calcium using in the treatment of occured electrocardiogram (ECG) abnormalities, there is not sufficient level of survey in the literature. So the aim of this study was to evaluate administration of iv calcium efficiency on vital signs and ECG.

详细描述

Hyperkalemia is a common problem in the emergency services and one of the life threatening metabolic emergencies. Serious hyperkalemia is mostly seen in patients who have known chronic renal failure or end stage renal disease, and also new diagnosis of acute renal failure can be appear with serious hyperkalemia. Paresthesia and weakness which is proceeded to flask paralysis can be observable, sharp ''T'' waves (the repolarization and relaxation of the ventricles), diminution of ''P'' waves (atrial depolarisation and contraction), long ''PR'' intervals (time frame from the beginning of atrial depolarization to the beginning of ventricular depolarization), or elongated ''QRS'' complexes (depolarisation and contraction of the ventricles), ''ST'' segment (end of the QRS complex to the beginning of the T wave) elevation, and serious ventricular arrythmias can be seen in electrocardiography. Calcium, insulin, beta adrenoceptor agonists, bicarbonate, diuretics, sodium polystyrene sulfonate and lastly dialysis are advised in treatment. Especially, avoiding evolution of serious arrythmias and İv calcium using in the treatment of occured ''ECG'' abnormalities, there is not sufficient level of survey in the literature. The group of Cochrane stated in systematic assessment report, which is published in 2005 about IV calcium administration, available dates are based on anecdotal and animal experiments. And in the researches that we have done, we did not find clinical human studies showing the benefits of calcium administration beyond the delivery of case reports . The aim of this study was to evaluate administration of İv calcium efficiency on vital signs and ECG.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

性别
All
接受健康志愿者

入选标准

  • All patients who had ECG changes due to hyperpotassemia (K>5.5 mmol/l)

排除标准

  • Arrest patients
  • Patients needed antiarrhythmic interventions
  • Patients need inotropic that may cause ECG changes
  • Patients need atropine during emergency treatment prior to Ca-gluconate
  • Patients needed cardioversion or defibrillation
  • Hyperpotassemia with myocardial infarction
  • In the presence of other situations which changes ECG for example pericarditis
  • Unstabile patients for ideal ECG
  • Digoxin usage
  • blood calcium level of > 10.5 mg/dl

结局指标

主要结局

ECG changes after the calcium infusion

时间窗: 10 minutes

次要结局

  • Blood pressure changes after the calcium infusion(10 minutes)
  • Pulse changes after the calcium infusion(10 minutes)

研究者

发起方
Haseki Training and Research Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Adnan Yamanoğlu

Emergency Medicine Specialist

Haseki Training and Research Hospital

研究点 (1)

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