Breathing control in radiotherapy.

Amsterdam UMC - Radiotherapy0 个研究点目标入组 90 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

•In order to be eligible to participate in this study, subjects must meet all of the following criteria:
•age >18 years
•adequate communication and understanding skills of Dutch language
•referred to or undergoing radiotherapy with DIBH at the department of radiation oncology of the Amsterdam UMC
•condition: KPS >70 or WHO PS max 1 (see 4.3 Exclusion criteria)
•signed informed consent (IC)

•Any potential subject with (a history of) any of the following conditions will be excluded from participation in this study:
•asthma controlled by medication
•moderately to severely impaired lung function (FEV1 <30% of predicted)
•resting PetCO2 >50 mmHg
•manifest cardiac failure
•hypertension uncontrolled by medication
•brain disease, and/or anomalies of the brain’s vasculature or previous TIA/CVA
•morbid obesity, i.e. BMI >40 kg/m2
•pneumothorax
•renal failure
•claustrophobia
•current pregnancy
•any 3T MRI contra-indications as stated by the AMC MR safety committee
•Furthermore, patients will be excluded if they have:
•any tumour that is not clinically definable on planning CT due to e.g. surrounding consolidation or atelectasis
•a tumour located within 2cm radius of main airways and proximal bronchial tree

发起方

Amsterdam UMC - Radiotherapy