Omega-6 to Omega-3 Fatty Acid Ratio and Higher Order Cognitive Function in 7-to 9-year-olds

Completed

• Conditions: Typical Development

• Registration Number: NCT01823419
• Lead Sponsor: University of North Carolina, Chapel Hill

Brief Summary

The purpose of this study is to investigate the role of the ratio of omega-6 to omega-3 fatty acids on executive functions. The investigators hypothesize that participants ages 7-9 years with a ratio closer to 4:1 will do better on tests of executive function than participants with a ratio closer to the purported Western diet norm of 15:1.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-10
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Status Verified: 2013-03
• Study First Submitted: 2013-03-20
• Study First Submitted QC: 2013-03-29
• Last Update Submitted: 2013-03-29
• Study First Posted: 2013-04-04
• Last Update Posted: 2013-04-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

• typically-developing

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Exclusion Criteria

• not fluent in English

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relation between executive function and n-6/n-3 fatty acid intake	up to 10 days	Executive function will be measured using a validated and standardized system known as CANTAB (Cambridge Neuropsychological Test Automated Battery) and correlated with the ratio of fatty acid intake. 24-hour diet recalls will be completed using the NDSR (Nutrient Data System for Research) software. Across one week, the children will be interviewed 3 times (two weekdays, one weekend day) about what they ate in the previous 24 hours. The dietary data will be averaged to arrive at the n-6/n-3 intake. The children will then come to lab for one visit where they will be assessed using the CANTAB.

Secondary Outcome Measures

Name	Time	Method
Temperament	Baseline	Temperament will be measured using a Rothbart written assessment completed by the caregiver.
Socioeconomic status	Baseline	Demographic information will be collected from caregiver using a lab-typical questionnaire.

Trial Locations

Locations (1)

UNC at Chapel Hill Nutrition Research Institute; 🇺🇸 Kannapolis, North Carolina, United States