Prospective Pakistan Registry of Echocardiographic Screening in Asymptomatic Pregnant Women
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- Number of participants found to have abnormal left ventricular function
研究概览
简要总结
Consecutive obstetric patients attending routine antenatal visits were enrolled in this ongoing registry. A standardized 2D transthoracic echocardiogram (TTE) protocol was employed. Ejection fraction (EF) was quantified using biplane Simpson's method.
详细描述
Consecutive obstetric patients attending routine antenatal visits were enrolled in this ongoing registry. A standardized 2D transthoracic echocardiogram (TTE) protocol was employed, including parasternal long and short, apical 4- and 2-chamber views. Continuous wave and pulse wave Doppler were used to assess left ventricular outflow tract (LVOT) gradients. Left ventricular (LV) function was quantified using biplane Simpson's method and visually assessed by two independent readers. Patients with significant valve disease or congenital heart disease underwent complete TTE. Those diagnosed with LV dysfunction or other cardiovascular diseases (CVD) were referred to the Cardio-Obstetrics clinic for further management and long-term follow-up.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Obstetric patients attending routine antenatal visits
排除标准
- •Patients refused to give consent for echocardiography or participation in the study
结局指标
主要结局
Number of participants found to have abnormal left ventricular function
时间窗: At the time of screening echocardiogram
Prevalence of Left ventricular dysfunction (Ejection Fraction\<55%)
Number of participants found to have abnormal heart valve function
时间窗: At the time of screening echocardiogram
Structural heart abnormalities (valvular heart lesions classified as mild, moderate and severe)
次要结局
- Number of participants found to have adverse Maternal outcomes(At the time of delivery)
- Number of participants found to have adverse Fetal outcomes(At the time of delivery)
研究者
Sabha Bhatti
Professor
National Institute of Cardiovascular Diseases, Pakistan