Epilepsy Surgery and Cognition, Psychiatric Function and Quality of Life - Outcome 10 Years or More After Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Epilepsy, Temporal Lobe
- Sponsor
- Oslo University Hospital
- Enrollment
- 102
- Locations
- 1
- Primary Endpoint
- Change in each study group on neuropsychological tests of language from baseline (preoperative) to current evaluation
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study will give important information about long term consequences of temporal lobe epilepsy surgery on cognition (memory, language, concentration etc), psychiatric function and quality of life.
Detailed Description
All patients in Norway who have undergone temporal lobe epilepsy surgery ten years ago or more, will be invited to participate. Two groups will be compared: patients who are younger than 50 years of age vs patients who are older than 50 years of age. The aim of the study is to improve preoperative information to future epilepsy surgery patients, to aid medical personnel (doctors, psychologists) in the selection of patients for surgery, and to improve knowledge of need for long term follow-up and rehabilitation.
Investigators
Eli Berit Kyte
Psychologist
Oslo University Hospital
Eligibility Criteria
Inclusion Criteria
- •Prior temporal lobe epilepsy surgery (10 years ago or more)
Exclusion Criteria
- •Intelligence quotient (IQ) less than 70
- •Other main language than Norwegian
Outcomes
Primary Outcomes
Change in each study group on neuropsychological tests of language from baseline (preoperative) to current evaluation
Time Frame: During single data collection session, aproximately 2 hours
Language will be measured by the subtest "Similarities" from Wechsler Adult Intelligence Scale - WAIS-III, results reported as raw scores from 1-worst to 33-best; Boston Naming Test-results reported as raw scores from 1-worst to 60-best; Letter Fluency from Delis Kaplan Executive Function Scale-D-KEFS, raw scores from 1-worst and up. All results will be converted to T-scores.
Change in each study group on neuropsychological tests of memory from baseline (preoperative) to current evaluation
Time Frame: During single data collection session, aproximately 2 hours
Memory will be measured by Rey Auditory Verbal Learning Test, results reported as raw scores from 1-worst to 15-best; and Diagnosticum für Cerebralschädugung-Revised - DCS-R, results reported as raw scores from 1-worst to 15-best. All results will be converted to T-scores with average 50, standard deviation 10.
Change in each study group on neuropsychological tests of executive function from baseline (preoperative) to current evaluation
Time Frame: During single data collection session, aproximately 2 hours
Executive function will be measured by the subtest "Digit Span" from WAIS-III, raw scores from 1-worst, to 30-best; Trails A and B from Halstead test battery, raw scores from 1-worst and up. All results will be converted to T-scores.
Change in each study group on neuropsychological tests of visuospatial abilities from baseline (preoperative) to current evaluation
Time Frame: During single data collection session, aproximately 2 hours
Visuospatial abilities will be measured by the subtest "Block Design" from WAIS-III, raw scores from 1-worst to 68-best. Results will be converted to T-scores.
Secondary Outcomes
- Score on quality of life inventory(During single data collection session, aproximately 2 hours)
- Score on depression questionaire(During single data collection session, aproximately 2 hours)
- Score on anxiety questionaire(During single data collection session, aproximately 2 hours)