Prediction of Chronic Renal Disease After Acute Kidney Injury in the Intensive Care Unit
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Assistance Publique - Hôpitaux de Paris
- Enrollment
- 425
- Locations
- 1
- Primary Endpoint
- Incidence of chronic kidney disease
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
The study aims to develop and validate a prediction score of chronic renal disease occurrence within 3 years after ICU discharge in patients who suffered an acute kidney failure during ICU stay and recovered normal renal function at 90 days following their discharge.
The primary study outcome is the incidence of chronic renal disease within the first 3 years after ICU discharge, defined by a lower glomerular filtration rate (GFR) under 60 mL/minute/1.73m2.
Detailed Description
As second objectives, the study aims to: * Evaluate the GFR decline in patients who had an underlying chronic kidney disease. * Evaluate factors associated with a persistent decreased GFR at day-90. * Characterization the clinical and biological phenotype of chronic renal disease in these patients. * Evaluate treatments provided to these patients according to CKD occurence. * Evaluate the rate of cardiovascular and thrombo-embolic morbidity-mortality. * Assess the quality of life every year for 3 years. * Evaluate the medico-economic burden of CKD.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patient ⩾ 18 years;
- •Patient suffering an acute kidney injury (defined by AKIN score ⩾1) during ICU stay;
- •Patient discharged alive from the ICU;
- •Patient's signed consent obtained;
- •Patient covered by a healthcare insurance.
Exclusion Criteria
- •Pregnant or breastfeeding woman;
- •SOFA score \< 1 (except for kidney assessment) at time of ICU admission;
- •End-stage of renal failure or dialysis treatment or renal transplantation prior to ICU admission;
- •Patient treated with dialysis at ICU discharge;
- •Immunosuppressive treatment prior to ICU admission;
- •Patient under legal incapacity (tutor or guardian protection);
- •Being unable to follow-up of the study;
- •Life expectancy expected shorter than 90 days;
- •Refusal to participate in the study;
- •Patient's main address is outside of Il de France region for the centers in this region;
Outcomes
Primary Outcomes
Incidence of chronic kidney disease
Time Frame: At 3 years
Incidence of chronic kidney disease defined by a decreased glomerular filtration rate (GFR) under 60 mL/minute/1.73m2.
Secondary Outcomes
- Progression of chronic renal disease defined by the slope of GFR decline(At 3 years)
- All-cause mortality(At 3 years)
- Progression of chronic renal disease defined by the number of patients with end-stage renal disease requiring dialysis or renal transplantation(At 3 years)
- Quality of life assessment(At the end of 1 year)
- Cost(At 3 years)
- Progression of the proteinuria(At 3 years)
- Occurrence of cardiovascular events and thromboembolic events(At 3 years)