CTRI/2024/08/072663Not yet recruitingPhase 4
Effect of ultrasound guided Erector spinae plane block and Serratus anterior plane block on inflammatory response in patients undergoing Modified radical mastectomy under general anaesthesia
Maulana Azad Medical College and Associated Lok Nayak Hospital1 site in 1 country50 target enrollmentStarted: August 30, 2024Last updated:
Trial Snapshot
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- 1. Serum IL-6 concentration in both the groups
Study Overview
Brief Summary
We are comparing the effect of ultrasound guided Erector spinae plane block and Serratus anterior plane block on inflammatory response in patients undergoing modified radical mastectomy under general anaesthesia. The primary objective of the study is to compare the effect of Serratus Anterior plane block and Erector spinae plane block on serum IL-6 and IL-10 levels in patients undergoing Modified Radical Mastectomy under general anaesthesia, taking a sample size of 50 patients for the study.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Masking
- Participant and Outcome Assessor Blinded
Eligibility Criteria
- Ages
- 18.00 Year(s) to 75.00 Year(s) (—)
- Sex
- Female
Inclusion Criteria
- •ASA grade 1, 2, 3 patients.
Exclusion Criteria
- •Bleeding diathesis
- •Local skin infection at the site of block
- •Allergy to local anaesthetics or adjuvants.
Outcomes
Primary Outcomes
1. Serum IL-6 concentration in both the groups
Time Frame: Baseline and 24 hours post-operatively
2. Serum IL-10 concentration in both the groups
Time Frame: Baseline and 24 hours post-operatively
Secondary Outcomes
- Serum cortisol concentrations in both the groups(Baseline and 24hrs postoperatively)
- Total consumption of intravenous Fentanyl in both the groups(During the duration of the surgery)
- Time at which the first rescue analgesia is requested by the patient postoperatively as assessed by the NRS pain score in both the groups(2hrs, 6hrs, 12 hrs and 24hrs postoperatively)
- Total amount of opioid consumption within 24 hours postoperatively in both the groups(24 hrs postoperatively)
Investigators
Sandeep J
Maulana Azad Medical College
Study Sites (1)
Loading locations...
Similar Trials
Not yet recruiting
Not Applicable
A study in which the participants are paediatric patients undergoing infraumbilical surgery with main outcome of the study being postoperative pain relief between ultrasound guided erector spinae plane block and caudal block.CTRI/2024/09/073379Vardhman Mahavir Medical College and Safdarjung Hospital70
Recruiting
Not Applicable
Efficacy of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Plane Block for Postoperative Pain Control Following Video-assisted Thoracoscopic Surgeries (VATS): Randomized Control TrialNCT07360028Ain Shams University50
Not yet recruiting
Not Applicable
comparison between erector spinae and paravertebral block for post operative pain in patients undergoing breast surgeriesCTRI/2024/08/072372DR SWATHI S128
Not yet recruiting
Phase 2/3
An ultrasound-guided back injection reduces pain after breast cancer surgery.CTRI/2025/03/083496Gandhi Medical College60
Not yet recruiting
Phase 2/3
A study to compare Erector spinae plane block and posterior quadratus lumborum block for post-op analgesia for lower abdominal surgeries.CTRI/2024/12/077861LLRM Medical College Department of Anaesthesiology80