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临床试验/NCT06363214
NCT06363214尚未招募不适用

Impact of Patient Blood Management (PBM) at the Schulthess Clinic A Quality Assurance and Quality Control Project in Major Orthopaedic and Spine Surgery

Schulthess Klinik0 个研究点目标入组 16,000 人开始时间: 2024年5月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
16,000
主要终点
Perioperative transfusion rates

研究概览

简要总结

Aim of this study is to analyze the transfusion requirements of allogenic blood products at the Schulthess Clinic for patients that had major orthopedic or major spine surgery between 2019 and 2024 order to identify patients at risk for transfusion. Moreover, impact of transfusion requirements and other measures of PBM on patient outcomes will be assessed. These data are required to further improve PBM at the Schulthess Clinic.

详细描述

At the Schulthess Clinic a significant reduction of RBC's, fresh frozen plasma (FFP) and platelets transfusion could be observed between 2018 and 2022 during the stepwise introduction of PBM for all patients undergoing major orthopedic and spine surgery. RBC, FFP and PT transfusion declined by 76.3%, 73.5% and 99.2% over the 5-year period. Unfortunately however, at the moment no detailed analysis with respect to risk factors for transfusion, specific interventions or outcomes is available. The hypothesis is that the already known reduction of allogenic blood product transfusion at the Schulthess Clinic can be attributed to patients undergoing major primary joint arthroplasties, revision operations and major spine surgery. We assume that patient and procedure related risk factors over time did not significantly change while we expect a major impact of changed transfusion requirements and the stepwise PBM implementation on patient outcomes.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
16 Years 至 99 Years(Child, Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients undergoing primary joint arthroplasties or revision surgery: CHOP Code: 81.51, 81.52, 81.52, 81.54
  • Patients undergoing major spine surgery: CHOP Code: 7A.6, 7A.7

排除标准

  • Patients who did not sign general informed consent

结局指标

主要结局

Perioperative transfusion rates

时间窗: 2019-2024

Administration of red blood cells, fresh frozen plasma and platelet concentrates (units)

Risk factors for perioperative transfusion Risk factors for perioperative transfusion Risk factorsfor perioperative transfusion

时间窗: 2019-2024

Identification of patient groups with increased transfusion rates

次要结局

  • Perioperative rates of coagulation products administered(2019-2024)
  • Clinical outcomes(2019-2024)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Christoph Hofer

Head of Anesthesia, Professor, Principal Investigator

Schulthess Klinik

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