IRCT20180417039339N1招募中3 期
Effect of verapamil on GLP-1R in type 2 diabetic patients receiving metformin and sitagliptin
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 46
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20 years 至 65 years（—）
- 性别
- All
入选标准
- •Signature of consent by patients
- •Age between 20 and 65 years
- •Elapsed at least three months from detection of T2DM
- •Baseline A1c <8.5%
排除标准
- •Pregnancy and lactation
- •Uncompensated heart failure
- •myocardial infarction or evidence of ischemic heart disease or other serious cardiac disease within the 12 weeks before randomization
- •History of epilepsy, cancer, cystic fibrosis, sickle cell anemia, peripheral vascular disease or cerebrovascular disease
- •known left ventricular dysfunction
- •hypotension (systolic pressure <90 mm Hg)
- •PR interval prolongation on EKG or any bradyarrhythmia (e.g. sick sinus syndrome, AV block)
- •Wolff-Parkinson- White [WPW] syndrome
- •Lown-Ganong-Levine syndrome
- •Concomitant use of drugs that affect blood glucose levels
- •Untreated hypothyroidism or active Graves' disease with hyperthyroidism
- •Serum creatinine >1.5 mg/dl ,GFR<60
- •Currently receiving insulin therapy
- •Total bilirubin , Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) > 1.5 x ULN
- •Hypersensitivity to verapamil or any component of the formulation
研究者
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