Generation of Cancer Antigen-Specific T-cells From Human Induced Pluripotent Stem Cells (iPSC) for Research and Potential Future Therapy
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- Availability of stored specimens and/or data
研究概览
简要总结
Background:
Researchers want to test if certain cells can be re-programmed into stem cells. Stem cells can keep reproducing for a long time. Cells made by stem cells can be turned into different types of cells. These include cancer-fighting cells, skin cells, etc. The stem cells generated in this study will be used to make specific tumor-fighting cells that can recognize different types of mutations in cancer cells. They may also help identify new tumor mutations that may not have been identified yet.
Objectives:
To test if a certain type of tumor-fighting cells can be re-programmed into stem cells.
Eligibility:
Participants in another Surgery Branch protocol who are at least 16 years old
Design:
Participants already gave samples of blood and/or tumor tissue in the other protocol. They do not need to come back to the clinic or give any other samples.
Participants will give consent for their samples to be used in this study.
Researchers will obtain cells from the samples. They will grow those cells in the lab. They will create stem cells from them.
Researchers will do genetic tests on the samples.
Most tests will not show important health results. But if they do, the participant will be invited to talk to a genetic counselor and get more detailed testing to confirm the results.
Some of the samples and results will be stored indefinitely. They may be used in future research. No personal information will be stored with them.
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详细描述
Background:
T-cells are potentially curative for patients with metastatic cancer, but many patients with cancer have T-cells that are terminally differentiated , a condition associated with treatment failure. We have observed that less differentiated T-cells have a greater capacity to proliferate, persist, and destroy large cancer deposits. Advances in regenerative medicine might allow the generation of rejuvenated T-cells from induced pluripotent stem cells (iPSC).
Objectives:
To reprogram patient specimens into induced pluripotent stem cells (iPSC) and differentiate them into different types of somatic cells with the goal to produce cancer antigen-specific T-cells.
To make stored specimens and/or data available to approved research laboratories and investigators.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Availability of stored specimens and/or data
时间窗: Approximately 10 years
Availability of stored specimens and/or data to approved research laboratories and investigators
Production of cancer antigen-specific T-cells
时间窗: Approximately 10 years
Reprogram patient specimens into induced pluripotent stem cells (iPSC) and differentiate them into different types of somatic cells
次要结局
未报告次要终点