Prospective study to validate the efficacy of cilostazol on variant angina
- Conditions
- Diseases of the circulatory system
- Registration Number
- KCT0000020
- Lead Sponsor
- Pusan National University Yangsan Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 50
Patients who present with chest pain in PNUYH,Gangneung ASAN H.,Haeundae Paik H.
? signing on consent form
? age : 20~80 years old
? diagnosis of variant angina as following the criteria
?. Resting anginal chest pain
?. Documented coronary vasospasm : anyone of A~C
A. CAG ( Reversible vasospasm ) : a or b
a. Provocation Test (Use of intravenous Ergonovine) : positive
b. Vasodilator Response Test ( Use of intracoronary Nitroglycerin)
: reversibility of baseline vasospasm ( Resolved vasospasm of =50%)
B. Echocardiogram
a. Provocation Test (Use of intravenous Ergonovine) : positive
C. Routine ECG or 24h ECG Holter monitoring
a. Transient ST-T wave
?. Exclusion of significant coronary arterial stenosis: anyone of A~D
A. CAG : No Culprit lesion (< 50% luminal narrowing )
B. CT-Coronary Angio : No significant lesion (<50% stenosis )
C. TMT : Negative
D. thalium SPECT : Normal uptake
? less than 20 year old or more than 80 years old
? mixed angina which has more than 50% of coronary artery stenosis
? contraindication of pletaal use
? chronic renal failure ( serum Cre > 2 mg/dL)
? ejection fraction < 40%
? vasospasm on left main
? pregnant woman
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method chest pain scale
- Secondary Outcome Measures
Name Time Method all adverse effect