Efficacy of Metformin in PCOS: Metabolic and Hormonal Factors
Not Applicable
- Conditions
- Polycystic Ovary Syndrome
- Registration Number
- NCT00317928
- Lead Sponsor
- Aarhus University Hospital Skejby
- Brief Summary
Hypothesis: Metformin treatment normalises hormone values and metabolic parameters in women with PCOS. Ovulation is restored and bleeding periods become regular.
Fifty women with PCOS (Rotterdam criteria) are randomised to either placebo or metformin for 6 months. After a wash-out period of 3 months, the opposite treatment is given for another 6 months. Measurements are performed before ech treatment period, every second month during treatment and after completing treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 50
Inclusion Criteria
- Diagnosis of PCOS
- Age 20 - 45
Exclusion Criteria
Diabetes
- Diabetes
- Hormonal treatment
- Pregnancy, lactation
- Periclimacteric
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method