Risk of Airborne Particulate matter: a Toxicological and Epidemiological hybrid Study
Completed
- Conditions
- respiratory tract inflammationthrombogenesis100188491008220610006436
- Registration Number
- NL-OMON32662
- Lead Sponsor
- niversiteit Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 32
Inclusion Criteria
healthy, non smoking, 18-35 years of age, living in students housing facilities at the campus of Utrecht University (de Uithof), good understanding of the Dutch language
Exclusion Criteria
lifetime diagnosis asthma or COPD
recent wheeze, shortness of breath, chronic cough
history of high blood pressure, angina pectoris or myocardial infarction
medication for respiratory or cardiovascular disease
diabetes mellitus
obesity
smoking or living in a household with a smoker
pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Respiratory and cardiovascular health will be assessed before and after the<br /><br>exposure. These will include recording of symptoms, spirometry (peakflow, FEV1,<br /><br>FVC, FEF25-75), nasal lavage, exhaled NO and CO, blood pressure, oxygen<br /><br>saturation in blood, heart rate, and blood sampling. Plasma samples and nasal<br /><br>lavage will be analyzed on inflammation markers.</p><br>
- Secondary Outcome Measures
Name Time Method <p>We will administer a time activity questionnaire to assess exposure to indoor<br /><br>sources (e.g. smoking, cooking), participation in traffic, and time spent<br /><br>outdoors. These measurements will be used to document the relative contribution<br /><br>of pre- and post experiment exposures, compared to exposure during the<br /><br>experiment.</p><br>