Comparison of Effects of Intravenous Dexmedetomidine and 2 percentage Lignocaine in Perioperative Hemodynamic stability and Post Operative Recovery profile in Laparoscopic Surgery

Aim is to compare the effects of  intravenous lignocaine and dexmedetomidine on  perioperative hemodynamic parameters in patients undergoing laparoscopic surgeries

Primary objective is to analyse the effects of perioperative hemodynamic stability.Secondary objective is to analyse the  intubation response,time to extubate,postoperative pain relief and pain at discharge from recovery in patients undergoing laparoscopic surgeries.A prospective,interventional,single centric, double blinded, randomized control trial.clinical study will be conducted after getting approval from the Institutional Ethical Committee.Patients were familiarized with the 10-point Visual Analog Scale VAS during the preanesthetic visit. In the operating room, standard multiparameter monitors were connected.Patients in Group D receive dexmedetomidine 0.5microgram per kilogram loading dose over 10 minutes, followed by 0.5 microgram per kilogram per hour infusion, while Group-L receive lidocaine hydrochloride 1.5 mg per kg slow bolus, followed by 1.5 milligram per kilogram per hour infusion,while Group-P 0.9 percentage Normal saline. Anesthetic induction was achieved with fentanyl 2.5  microgram per kilogram  and propofol 2 milligram per kilogram until loss of verbal command. Endotracheal intubation was performed with Atracurium 0.5mg per kilogram.  Anesthesia was maintained with an oxygen/air/sevoflurane mixture 1 MAC and atracurium. After induction continuous hemodynamic parameters is monitored in regular predefined time scale through out the procedure.Intraabdominal pressures,end tidal Co2 and MAC is monitored through out the procedure.After the specific specimen is out, then sevoflurane and study drug infusion will be stopped and extubation will stared after 20-30  minutes from the time of specimen out.Residual neuromuscular blockade was reversed with neostigmine 0.05 milligram per kilogram and glycopyrrolate 0.005 milligram per kilogram. Immediately after extubation, RASS and VAS score is assessedand 20 minutes after extubation repeat VAS will be  monitored.Patients were transferred to the post anesthesia care unit PACU after successful tracheal extubation. Heart rate HR and mean arterial pressure MAP were monitored at regular intervals. Hypotension 20 percentage MAP fall below baseline) was managed with crystalloid boluses and Phenylepherine 10-50 microgram. Bradycardia HR < 45 beats/min was managed with IV atropine 0.6 milligram.