Observational study to assess correlation between gene present in DNA which cause fast or slow metabolism of drug (genotype), concentration of drug in blood (phenotype) and prakriti in patients on phenytoin monotherapy
Not Applicable
- Conditions
- Health Condition 1: null- patients who are on phenytoin monotherapy
- Registration Number
- CTRI/2011/06/001782
- Lead Sponsor
- Investigator initiated study
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
1 Patients who are on phenytoin monotherapy for
prophylaxis or treatment since one month
2 Patients willing to give informed consent
Exclusion Criteria
1 Age below 18 years
2 Patients with clinical H/o hepatic failure, renal failure,
hypoalbuminemia, anaemia
3 Patients suffering from psychological disorder
4 Pregnant and lactating women
5 Patients of the same family
6 Patients taking drugs which induce or inhibit CYP2C9
and CYP2C19 enzymes
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1.correlation between phenotype and genetic polymorphism of cyp2c9 and cyp2c19. <br/ ><br>2. correlation between genetic polymorphism of cyp2c9 and cyp2c19 and prakriti. <br/ ><br>3. correlation between penotype and genetic polymorphism of cyp2c9 and cyp2c19.Timepoint: 16 weeks
- Secondary Outcome Measures
Name Time Method nilTimepoint: nil