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临床试验/NCT05938049
NCT05938049尚未招募不适用

Carotid Doppler and Inferior Vena Cava Measuerments for Volume Guided Management in Acute Kidney Injury Patients

Assiut University0 个研究点目标入组 60 人开始时间: 2024年12月最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
60
主要终点
percentage of participants with improved urine out put in ml/kg/h in groups A and B.

研究概览

简要总结

  1. Evaluate Inferior Vena Cava Indices (Diameters , IVC-CI)&carotid doppler measurements (corrected Carotid Flow Time ,Carotid Blood Flow ,Carotid Artery Peak Velocity Variations) as Non-Invasive Technique for volume guided management in AKI Patient.
  2. Estimate correlation between IVC (Diameters , IVC-CI) & carotid doppler measurements (corrected Carotid Flow Time ,Carotid Blood Flow ,Carotid Artery Peak Velocity Variations) as Non-Invasive Technique for volume guided management in AKI Patient.

详细描述

Acute kidney injury affects increasing numbers of patients worldwide, it was estimated approximately 15% of all subjects treated in hospitals develop Acute kidney injury,even a small increase in serum creatinine may be associated with increased risk of mortality , Oliguric AKI it imposes a great challenge for fluid management.

Recently, ultrasonography for estimating volume status has been widely recommended because of its non-invasive nature, ease of acquisition, and reproducibility of measurements.Among these ultrasound modalities, ultrasonographic assessment of the inferior vena cava & Carotid doppler measurements .

In spontaneously breathing patients, the inferior vena cava (IVC) diameter and the IVC Collapsibility Index (IVC-CI) have been shown to correlate with the volume status and central venous pressure (CVP) . also has been shown to indicate fluid status in children , ventilated patients and healthy volunteers .

corrected Carotid Flow Time (CFT) unaffected by respiration predicting fluid responsiveness that has shown promising results.Studies to date have shown that corrected CFT increases in response to fluid administration or consumption , and decreases in response to volume removal in dialysis and blood donation .

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Patients diagnosed with Acute Kidney Injury
  • age must be more than 18 years

排除标准

  • Morbid obesity (BMI >35)
  • End Stage Renal Disease (ESRD) on dialysis
  • Sever ventricular dysfunction, valvular heart disease
  • Carotid stenosis >50%
  • chronic obstructive pulmonary disease.
  • Pregnancy & tense ascites

结局指标

主要结局

percentage of participants with improved urine out put in ml/kg/h in groups A and B.

时间窗: at 48 hours

percentage of participants with improved urine out put in ml/kg/h in groups A and B.

percentage of participants with improved serum creatinine level in µmol/L in groups A and B.

时间窗: at 48 hours

percentage of participants with improved serum creatinine level in µmol/L in groups A and B.

次要结局

  • percentage of participants with improved mean arterial blood pressure in mmHg in groups A and B.(at 48 hours)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ayman Abdallah Mahmoud

principal investigator

Assiut University

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