Cardiac Magnet Resonance Imaging to Evaluate of Dynamic T2 Preparation Puls by Patient With Shunt or Patients With Chronic Obstructive Pulmonary Disease (COPD)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- ventricular volumetry
研究概览
简要总结
There is preliminary evidence that a dynamic T2 Preparations Puls sequence by cardiac magnet resonance imaging can differentiate between oxygenated and deoxygenated blood.
In adult patients with inborn heart defects this has not yet been researched. Therefore,patients with ventriculoperitoneal shunt, septal and atrio-septal shunt should be examined. Also, patients with chronic obstructive pulmonary disease should be examined.
The aim of this study is the validation of a novel magnet resonance sequence in terms of a distinction of oxygenated blood to deoxygenated blood in comparison to invasive method of measuring cardiac catheterization.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with atrial septal defect (ASD) or ventricular septal defect (VSD) and COPD
- •written informed consent
排除标准
- •patients with ST-elevation
- •contraindication for MRI
- •heavy kidney disease
- •pregnant or breast feeding women
结局指标
主要结局
ventricular volumetry
时间窗: baseline
ventricular volumetry by Cardiac Magnet Resonance Imaging using dynamic T2 Preparation Puls for arithmetical determination of end-systolic volume, end-diastolic volume, ejection fraction, stroke volume and myocardial weight
次要结局
- oxygen partial pressure(baseline)
- Major adverse cardiac events(12 month after procedure)
- carbon dioxide partial pressure(baseline)
- pH-value(baseline)
- Blood gas analysis(baseline)
研究者
Klinik für Kardiologie, Pneumologie und Angiologie
Dr. med. Britta Butzbach
Heinrich-Heine University, Duesseldorf