Thyroid Dysfunction and Obstetric Complications

Withdrawn

• Conditions: Pregnancy
• Interventions: Biological: blood samples

• Registration Number: NCT02815501
• Lead Sponsor: Centre Hospitalier Universitaire, Amiens

Brief Summary

Obstetric complications are common and can be responsible for maternal and foetal morbidity and mortality. Thyroid dysfunction has been identified as a possible cause of obstetric complications.

Many studies have been conducted to estimate the prevalence and define the nature of obstetric complications observed in patients with thyroid dysfunction. However, women with obstetric complications are not systematically screened for thyroid dysfunction and no published study has evaluated the prevalence of thyroid dysfunction in women with an obstetric complication. As no consensus has been reached concerning systematic screening for thyroid dysfunction in pregnant women, the identification of new high-risk populations could possibly result in a change of clinical practice.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03-01
• Study First Submitted: 2016-06-24
• Study First Submitted QC: 2016-06-27
• Study First Posted: 2016-06-28
• Primary Completion: 2017-10-26
• Study Completion: 2017-10-26
• Status Verified: 2020-07
• Last Update Submitted: 2020-07-13
• Last Update Posted: 2020-07-15

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: Female
• Target Recruitment: Not specified

Inclusion Criteria

women attending the emergency room and/or hospitalised or followed for:

• Spontaneous and/or repeated miscarriage
• Foetal death
• Pre-eclampsia
• Retroplacental haematoma
• Post-partum haemorrhage
• Premature delivery
• who consent to participate in the study.
• Assessment of these women will include blood samples for a laboratory work-up and anti-thyroid antibodies.

Exclusion Criteria

• normal pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
women	blood samples	attending the emergency room and/or hospitalised or followed for: Spontaneous and/or repeated miscarriage Foetal death Pre-eclampsia Retroplacental haematoma Post-partum haemorrhage Premature delivery Blood samples

Primary Outcome Measures

Name	Time	Method
Prevalence of thyroid dysfunction	Day 0	Estimate the overall and individual prevalence of thyroid dysfunction (hypothyroidism, hyperthyroidism and thyroid autoimmunity) in patients with obstetrical accident

Trial Locations

Locations (1)

CHU Amiens; 🇫🇷 Amiens, France