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The efficacy and mechanism of Panax notoginseng in the treatment of 'anti-platelet drug resistance'

Phase 1
Recruiting
Conditions
Anti-platelet drug resistance
Registration Number
ITMCTR2000003884
Lead Sponsor
Shaanxi Hospital of Traditional Chinese Medicine
Brief Summary

Not available

Detailed Description

Not available

Recruitment & Eligibility

Status
Recruiting
Sex
All
Target Recruitment
Not specified
Inclusion Criteria

1. Patients who meet the diagnostic criteria of Chinese guidelines for diagnosis and treatment of acute ischemic stroke 2010 and aspirin semi resistance diagnosis issued by neurology branch of Chinese Medical Association;
2. Patients who agree to participate in the clinical trial and sign the informed consent form;
3. Patients aged 45-65 years, with no gender limit and taking single antiplatelet drugs;
4. Patients with Essen stroke risk score <= 3;
5. Patients who no longer use traditional Chinese medicine with the function of promoting blood circulation and removing blood stasis in the observation period.

Exclusion Criteria

1. Patients with transient ischemic attack and cerebral infarction need double antibody;
2. Patients with cerebral infarction, cerebral hemorrhage, cerebral arteritis, brain tumor, brain trauma, brain parasitic disease and rheumatic heart disease;
3. Patients with bleeding tendency or severe bleeding within 3 months;
4. Patients with severe liver, kidney, hematopoietic and metabolic diseases;
5. Patients with disabilities prescribed by law (blindness, deafness, dumb, mental retardation, mental disorder and physical disability caused by other reasons) affect the evaluators of neurological impairment;
6. Patients who are suspected or have a history of alcohol and drug abuse, or other situations that, according to the judgment of the researchers, have the possibility of reducing or complicating the enrollment;
7. Patients who are participating in other clinical trials or have participated in other drug clinical trials within 3 months.

Study & Design

Study Type
Interventional study
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Platelet aggregation function (PAgT);Thromboxane A2;Prostacyclin (PGI2);
Secondary Outcome Measures
NameTimeMethod
Adenosine diphosphate;
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