Assessing the frequency, phenotype and function of plasmacytoid dendritic cells and T cells in blood and skin of patients with skin fibrosing disorders

Completed

• Conditions: 10003816; 10010761; 10040790; Systemic sclerosis - scleroderma / Localized scleroderma - morphea / Eosinophilic fasciitis - ?

• Registration Number: NL-OMON47886
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 150

Inclusion Criteria

-Age range: 18 - 75 years
-Diagnosed with systemic sclerosis, localized scleroderma, eosinophilic fasciitis or psoriasis.

Exclusion Criteria

--Current use of coumarin derivatives
-Current use of cyclophosphamide
-IV corticosteroids in the last 14 days for inclusion
-Age <=17 years
-Patients with contra-indications for undergoing a skin biopsy (for example allergic to topical anesthetics)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Number, phenotype and function of plasmacytoid dendritic cells and T cells in<br /><br>the skin and blood of patients suffering from SSc, LS or EF and in healthy<br /><br>controls / patients with psoriasis.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>