Determining the Accuracy of Naadi (Siddha Pulse) Examination in Detecting the cases with Thyroid Pathology Reporting at National Institute of Siddha - A Prospective Blinded Clinical Diagnostic Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 140
- 试验地点
- 1
研究概览
简要总结
Naadi Siddha Pulse examination is a traditional Siddha diagnostic method based on pulse assessment
This study aimed to evaluate its diagnostic accuracy in detecting the participants with Thyroid pathology using thyroid function tests and sonography as the reference standard
PRIMARY OBJECTIVE
To determine the diagnostic accuracy of NaadiSiddha pulse examinationin the detection of participants with Thyroid pathology
SECONDARY OBJECTIVES
To determine the positive predictive value PPV and negative predictive value NPV of the Naadi examinationin diagnosing participants with Thyroid pathology
To determine the positive likelihood ratio and negative likelihood ratio of the Naadi examination in diagnosing participants with Thyroid pathology
To determine the diagnostic performance of Naadi examination using receiver operating characteristic curve analysis and area under the curve
To document the Yakkai Ilakkanam for the participants with Thyroid pathology through validated questionnaires
STUDY TYPE
Observational Study
STUDY DESIGNA Prospective Blinded Diagnostic Study
Study Setting
Outpatient and Inpatient department
Ayothidoss Pandithar Hospital
National Institute of Siddha
Chennai 600047
Study Timeline 18 months
Sample size 280
NUMBER OF CASES140
NUMBER OF CONTROLS 140
PRIMARY OUTCOME Specificity and Sensitivity of Naadiexamination for the diagnosis of cases with Thyroid pathology will be determined
SECONDARY OUTCOME
Positive Predictive Value PPV and Negative Predictive Value NPV of Naadi examination for participants with Thyroid pathology will be estimated
Positive Likelihood Ratio and Negative Likelihood Ratio of Naadi examination for participants with Thyroid pathology will be calculated
Diagnostic performance of Naadi examination for participants with Thyroid pathology will be assessed using ROC curve analysis and Area Under the Curve
Yakkai Ilakkanam for participants with Thyroid pathology will be documented through validated questionnaires
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Presence Of Thyroid Pathology.
排除标准
- •CASES Known Case Of Cardiac Diseases Or Kidney Diseases Or Arterial Diseases Vulnerable Group Like Pregnant And Lactating women children geriatric and cognitive impaired patients CONTROLS Known case of Malignant Carcinoma or OCP or Parathyroid pathology or Thyroidectomy Participants who are on medications like Steroids lithium OCP that affect Thyroid functions Vulnerable group like pregnant and lactating women children geriatric and cognitive impaired patients.
研究者
Dr M Maheswari
National Institute of Siddha