Pangenomic Study During Alcoholic Cirrhosis
Completed
- Conditions
- Alcoholic Cirrhosis
- Interventions
- Genetic: DNA extraction
- Registration Number
- NCT01065233
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
Hepatocellular carcinoma (HCC) is a frequent complication of cirrhosis. Occurrence of HCC could be linked with multiple functional region of genome.
The determining of a genomic mapping of " single nucleotide polymorphisms " (SNPs) permit to perform some genetic link studies with pathologies without clear hereditary disposition.
In this study, the investigators will identify predictives genetic polymorphism of HCC.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1325
Inclusion Criteria
- 35 to 70 years old
- Compensated cirrhosis or not
- Caucasian origin of the parents
- Patient with cirrhosis (histological proof or obvious)
Exclusion Criteria
- HIV, HBV, HCV positive
- Known Homozygotia (C282Y+/+)
- Important hepatocytary iron overload for patient with resection
- HCC non histologically prooved
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description alcoholic cirrhosis without viral infection DNA extraction patient with alcoholic cirrhosis without viral infection alcoholic cirrhosis with viral infection DNA extraction patient with alcoholic cirrhosis with viral infection (300 patients)
- Primary Outcome Measures
Name Time Method Existence of HCC and Pangenomic analysis of DNA polymorphism Existence of HCC and determination of which genetic polymorphism are predisposing to HCC or preventing for HCC
- Secondary Outcome Measures
Name Time Method cirrhosis severity (compensated or not) Analysis of the genetic polymorphism involved in the severity of cirrhosis
Trial Locations
- Locations (4)
Paul Brousse UH
🇫🇷Paris, France
Nantes UH
🇫🇷Nantes, France
Jean Verdier UH
🇫🇷Paris, France
Rennes UH
🇫🇷Rennes, France