Selinexor in Combination With Immunomodulator to Treat Relapsed/Refractory Multiple Myeloma Patients
试验速览
- 阶段
- 2 期
- 状态
- 招募中
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Overall Response Rate (ORR)
研究概览
简要总结
Multiple myeloma (MM) is an incurable plasma cell cancer that almost all patients eventually relapse despite advancement in treatment strategies. B-cell maturation antigen (BCMA) is a cell surface receptor that expressed primarily by malignant and normal plasma cells. This is a single-arm that includes three arms, Selinexor(ATG-010) in Combination with Immunomodulator (Thalidomide/ Pomalidomide/ Lenalidomide）and Dexamethasone to Treat Relapsed/Refractory Multiple Myeloma Patients. To evaluate efficacy and safety of Selinexor in combination with Immunomodulator and Dexamethasone in RRMM patients received at least one prior lines of therapy.
详细描述
This is a single-arm and open-label phase II study of Relapsed/Refractory Multiple Myeloma patients who have received at least one prior lines of treatment therapy; This study includes three experimental arms. Arm I is given XTd regimen (ATG-010 60mg/d QW, Thalidomide 100mg/d and Dexamethasone 40mg/d QW) in approximately 30 subjects. Arm II is given XRd regimen (ATG-010 60mg/d QW, Lenalidomide 25mg/d d1-21 and Dexamethasone 40mg/d QW) in approximately 30 subjects, Arm III is given XPd（ATG-010 60mg/d QW, Pomalidomide 4mg/d d1-21 and Dexamethasone 40mg/d QW ) in approximately 30 subjects,The three arms are 4 weeks per cycle and include a total of 12 cycles.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients must meet all of the following inclusion criteria to be eligible to enroll in this study:
- •Known and written informed consent (ICF) voluntarily.
- •Age ≥ 18 years and ≤ 75 years.
- •Patients with multiple myeloma who have received first-line treatment (induction, autologous transplantation and maintenance as the same first-line treatment) and achieved at least partial remission in induction.
- •At or after accepting first-line regimen, subjects must have progression disease (PD) recorded which is determined by researcher according to IMWG criteria.
- •Any clinically significant non-hematological toxicities (except for hair loss, peripheral neuropathy, which is otherwise stipulated in Article 13 of the exclusion criteria) that relevant to previous therapies must have resolved to ≤Grade 2 prior to first dose of study drug.
- •Left ventricular ejection fraction#LVEF #≥50% by an echocardiogram or MUGA scan in 42 days before the first administration
- •Adequate hepatic function: total bilirubin < 2× upper limit of normal (ULN) (for patients with Gilbert's syndrome, a total bilirubin of < 3× ULN is required), AST < 2.5× ULN, and ALT < 2.5× ULN.
- •Adequate renal function: estimated creatinine clearance ≥ 20 mL/min (calculated using the formula of Cockroft-Gault).
- •Eastern Cooperative Oncology Group (ECOG) Performance Status of 0, 1, or
- •Measurable MM as defined by at least one of the following:
- •Serum M-protein (SPEP) ≥ 10 g/L
- •24 hours-Urinary M-protein excretion ≥ 0.2 g (200 mg)
- •Serum FLC ≥ 100 mg/L with abnormal FLC ratio
- •Expected survival is more than 6 months.
- •Adequate hematopoietic function (no blood transfusion within 2 weeks and no G-CSF/GM-CSF supportive treatment within 1 week prior to screening test):
- •Hemoglobin level ≥ 80 g/L
- •ANC ≥ 1,000/mm3 (1.0×109/L)
- •Platelet count ≥ 75,000/mm3 (75×109/L)
- •Female patients of childbearing potential must meet below two criteria:
- •must agree to use effective contraception methods since signature in ICF, throughout the study and for 3 months following the last dose of study treatment.
- •must have a negative serum pregnancy test at screening. Note: A woman is considered of childbearing potential following menarche and until becoming postmenopausal (defined as no menstrual period for a minimum of 12 months) or permanently sterile (having undergone a hysterectomy, bilateral salpingectomy or bilateral oophorectomy). A woman who is taking oral contraceptive or using intrauterine device is considered of childbearing potential.
- •Male patients (including those who have received vasectomy) must use a condom if sexually active with a female of child-bearing potential throughout the study and for 3 months following the last dose of study treatment.
排除标准
- •Patients who meet any of the following criteria will not be enrolled:
- •Asymptomatic (smoldering) MM.
- •Plasma cell leukemia.
- •Documented active amyloidosis.
- •Previously refractory or intolerant to immunomodulators.
- •Pregnancy or breastfeeding.
- •Major surgery was performed within 4 weeks prior to the first study.
- •Patients with active, unstable cardiovascular diseases, fits any of the following:
- •Symptomatic ischemia, or
- •Uncontrolled clinically-significant conduction abnormalities (e.g., patients with ventricular tachycardia on antiarrhythmics are excluded; patients with first-degree atrioventricular (AV) block or asymptomatic left anterior fascicular block/right bundle branch block (LAFB/RBBB) are allowed), or
- •Congestive heart failure (CHF) of New York Heart Association (NYHA) ≥ Grade 3, or
- •Acute myocardial infarction (AMI) within 3 months prior to the first dose of study drug.
- •Uncontrolled active infection within 1 week prior to the first dose of study drug.
- •Known HIV positive.
- •Known active hepatitis A, B, or C infection; or known positive for HCV RNA or HBsAg. (Note: patients with HBsAg negative but HBc Ab positive need further HBV-DNA test, excluded if HBV-DNA ≥103 , if HBV-DNA # 103 need anti-viral drugs)
- •Prior malignancy that required treatment or has shown evidence of recurrence (except for skin basal-cell carcinoma and in-situ carcinoma including squamous cell carcinoma, bladder cancer in situ, endometrial cancer in situ, cervical cancer in situ/atypical hyperplasia, prostate cancer incidental finding (T1a or T1b), or breast cancer in situ) within 5 years prior to the first dose of study drug.
- •Active GI dysfunction interfering with the ability to swallow tablets, or any GI dysfunction that could interfere with absorption of study treatment.
- •Grade ≥ 3 peripheral neuropathy, and Grade ≥ 2 painful neuropathy, within 3 weeks prior to the first dose of study drug.
- •Previous history of deep vein thrombosis.
- •Serious, active psychiatric, or medical conditions which, in the opinion of the Investigator, could interfere with study treatment.
- •Participation in an investigational anti-cancer clinical study within 3 weeks or 5 half-lives (T1/2) prior to the first dose of study drug.
- •Received ASCT within 12 weeks prior to the first dose of study drug or previous allogeneic stem cell transplantation (no time limitation).
- •Treatment with an approved or trial anticancer drug was given within 4 weeks prior to the first study.
- •Known intolerance to or contraindication for glucocorticoid therapy.
- •Prior exposure to a SINE compound.
研究组 & 干预措施
Arm I: Selinexor+Thalidomide+Dexamethasone
Arm I is given XTd regimen Selinexor 60mg/d QW, Thalidomide 100mg/d, d1-28 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Selinexor (Drug)
Arm I: Selinexor+Thalidomide+Dexamethasone
Arm I is given XTd regimen Selinexor 60mg/d QW, Thalidomide 100mg/d, d1-28 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Thalidomide (Drug)
Arm I: Selinexor+Thalidomide+Dexamethasone
Arm I is given XTd regimen Selinexor 60mg/d QW, Thalidomide 100mg/d, d1-28 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Dexamethasone (Drug)
Arm II: Selinexor+Lenalidomide+Dexamethasone
Arm II is given XRd regimen Selinexor 60mg/d QW, Lenalidomide 25mg/d, d1-21 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Selinexor (Drug)
Arm II: Selinexor+Lenalidomide+Dexamethasone
Arm II is given XRd regimen Selinexor 60mg/d QW, Lenalidomide 25mg/d, d1-21 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Lenalidomide (Drug)
Arm II: Selinexor+Lenalidomide+Dexamethasone
Arm II is given XRd regimen Selinexor 60mg/d QW, Lenalidomide 25mg/d, d1-21 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Dexamethasone (Drug)
Arm III: Selinexor+Pomalidomide+Dexamethasone
Arm III is given XPd regimen Selinexor 60mg/d QW, Pomalidomide 4mg/d, d1-21 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Selinexor (Drug)
Arm III: Selinexor+Pomalidomide+Dexamethasone
Arm III is given XPd regimen Selinexor 60mg/d QW, Pomalidomide 4mg/d, d1-21 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Pomalidomide (Drug)
Arm III: Selinexor+Pomalidomide+Dexamethasone
Arm III is given XPd regimen Selinexor 60mg/d QW, Pomalidomide 4mg/d, d1-21 and Dexamethasone 40mg/d QW) in approximately 30 subjects. 4 weeks per cycle and include a total of 12 cycles.
干预措施: Dexamethasone (Drug)
结局指标
主要结局
Overall Response Rate (ORR)
时间窗: Assessed from the date of first dose of study treatment until the date that PD assessed up to 12months
ORR in each arm: partial response (PR) + very good partial response (VGPR) + complete response (CR)
次要结局
- Minimal Residual Disease (MRD)(12 months)
- Overall Survival (OS)(12 months)
- Progression-Free Survival (PFS)(12 months)
- Duration of Response (DOR)(12 months)
- Disease Control Rate (DCR)(12 months)
- Clinical Benefit Rate (CBR)(12 months)
- Number of Participants with Adverse Events(From first dose of study drug administration to end of treatment (up to 12 months))
研究者
Juan Du
Chief physician, professor
Shanghai Changzheng Hospital