Effect of Kinetic Chain Exercises on Muscle Strength, Joint Position Sense and Quality of Life in Children with Haemophilia.

Not Applicable

Not yet recruiting

• Conditions: Hemophilia a; Muscle Strength; Joint Position Sense; Quality of Life (QOL)

• Registration Number: NCT06649175
• Lead Sponsor: Cairo University

Brief Summary

The goal of this clinical trial is to learn if there are effect of close kinetic chain exercises on muscle strength, joint position sense and Quality of life in children with haemophilia? Null hypothesis

It will be hypothesized that:

There is no effect of close kinetic chain exercises on muscle strength, joint position sense and Quality of life in children with haemophilia.

Detailed Description

Sample size estimation will be carried out to determine the recruited number of children selected randomly from Out Patient clinic of Atfal Misr hospital, Cairo governorate to participate in this study. The study targets male children with hemophilia A.

They will be selected based on the following:

Inclusion criteria:

1. Their chronological age will be 5-7yeasr.

2. All children will receive prophylaxis therapy.

3. They will able to stand and walk independently.

4. They will be able to follow instructions during evaluation and treatment.

Exclusive criteria:

The children will be excluded if they have one of the following:

1. Visual or auditory problem.

2. Radiographic changes as bone erosions, destruction, or joint subluxation, or congenital or acquired skeletal deformities in both lower limbs.

3. Surgical procedures performed six weeks prior to or during study.

4. Bleeding in joint 2 week prior to assessment.

Study Timeline

• Status Verified: 2024-03
• Study First Submitted: 2024-10-17
• Study First Submitted QC: 2024-10-17
• Last Update Submitted: 2024-10-17
• Study First Posted: 2024-10-18
• Last Update Posted: 2024-10-21
• Study Start: 2024-11-01
• Primary Completion: 2024-11-30
• Study Completion: 2025-03-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Male
• Target Recruitment: 40

Inclusion Criteria

• 1. Their chronological age will be 5-7yeasr. 2. All children will receive prophylaxis therapy. 3. They will able to stand and walk independently. 4. They will be able to follow instructions during evaluation and treatment.

Exclusion Criteria

• The children will be excluded if they have one of the following:

  1. Visual or auditory problem.
  2. Radiographic changes as bone erosions, destruction, or joint subluxation, or congenital or acquired skeletal deformities in both lower limbs.
  3. Surgical procedures performed six weeks prior to or during study.
  4. Bleeding in joint 2 week prior to assessment.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
a) Assessment of muscle strength:	baseline only	The isometric muscle strength of bilateral knee extensors muscles will be measured with a handheld dynamometer.

Secondary Outcome Measures

Name	Time	Method
b) Assessment of knee joint position sense.	baseline only	Knee joint position sense will be measures with a Saunders digital inclinometer.

Trial Locations

Locations (1)

Out Patient clinic of Atfal Misr hospital; 🇪🇬 Cairo, Egypt