Radiomics for Prediction of Long Term Survival and Local Failure After Stereotactic Radiotherapy for Brain Metastases

Completed

• Conditions: Metastases, Neoplasm

• Registration Number: NCT02265549
• Lead Sponsor: Maastricht Radiation Oncology

Brief Summary

Published prognostic scores have limitations in prediction of long term survival after stereotactic radiotherapy for brain metastases. Moreover, no validated tools are available for prediction of local failure. The value of radiomics is evaluated in this perspective.

Detailed Description

Sensitivity is low for prediction of long term survival of currently available prognostic scores for brain metastases. First the current clinical models will be optimized with a new prognostic model and nomogram. Radiomics is a tool to analyze tumor characteristics based on CT and MR images. These tumor characteristics may reflect tumor biology and outcome. Therefore it is investigated if radiomics improves prediction of long term survival after stereotactic radiotherapy for brain metastases. Moreover, the predictive value of radiomics for local failure is investigated.

Study Timeline

• Study Start: 2014-05
• Primary Completion: 2014-09-04
• Study Completion: 2014-09-04
• Study First Submitted: 2014-10-01
• Study First Submitted QC: 2014-10-10
• Study First Posted: 2014-10-16
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-25
• Last Update Posted: 2018-01-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 155

Inclusion Criteria

• Cerebral metastasized patients

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Sensitive value of 12 months local failure after stereotactic radiotherapy for brain metastases with radiomics	1 year	Sensitivity of 12 months local failure after stereotactic radiotherapy for brain metastases with radiomics. Radiomics is a tool to analyze tumor characteristics based on CT and MR images.
Sensitive value of 12 months survival after stereotactic radiotherapy for brain metastases with radiomics	1 year	Sensitivity of 12 months survival after stereotactic radiotherapy for brain metastases with radiomics. Radiomics is a tool to analyze tumor characteristics based on CT and MR images.

Secondary Outcome Measures

Name	Time	Method
Negative predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics.	1 year	Negative predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics.
Specificity of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics.	1 year	Specificity of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics.
Positive predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics.	1 year	Positive predictive value of 12 months survival and local failure after stereotactic radiotherapy for brain metastases with radiomics.

Trial Locations

Locations (1)

Maastro Clinic; 🇳🇱 Maastricht, Netherlands