The Effect of Inactive and Active Vitamin D on Serum Sclerostin/dickkopf1 Levels
Phase 4
- Conditions
- Osteoporosis
- Interventions
- Registration Number
- NCT01765010
- Lead Sponsor
- Seoul National University Hospital
- Brief Summary
The purpose of this study is to compare the effect of inactive and active vitamin D on serum sclerostin and dickkopf1 levels.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Male
- Target Recruitment
- 88
Inclusion Criteria
- Healthy male volunteer older than 20 years
Exclusion Criteria
- Subjects with bone and mineral metabolism disorders
- Subjects with kidney or liver diseases
- Subjects with uncorrectable hypercalcemia or hypocalcemia
- Subjects with chronic gastrointestinal disorders or malabsorption
- Subjects taking medication related to bone loss
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Arm && Interventions
Group Intervention Description Placebo control Placebo Placebo control Cholecalciferol 1000IU Cholecalciferol Cholecalciferol 1000IU qd for 8 weeks alfacalcidol Alfacalcidol alfacalcidol 0.5ug qd for 8 weeks Calcitriol Calcitriol Calcitriol 0.25ug qd for 8 weeks
- Primary Outcome Measures
Name Time Method Change of serum sclerostin level 8 weeks later Change of serum Dickkopf1 level 8 weeks later
- Secondary Outcome Measures
Name Time Method Change of serum c-telopeptide level 8 weeks later Change of serum bone-specific alkaline phosphatase level 8 weeks later Change of serum calcium level 8 weeks later Change of serum parathyroid hormone level 8 weeks later
Trial Locations
- Locations (1)
Seoul National University Medical School
🇰🇷Seoul, Korea, Republic of