Clinical and Radiographic Evaluation of Nano-crystalline Hydroxyapatite Silica Gel in the Treatment of Human Periodontal Intrabony Defects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Clinical attachment level
研究概览
简要总结
A clinical and radiographic evaluation of Nano-crystalline hydroxyapatite silica gel in comparison with open flap debridement for management of periodontal intrabony defects.
详细描述
Thirty patients suffering from advanced chronic periodontitis were included in this randomized controlled clinical trial. Each subject contributed matched two- or three-walled intrabony defects. Patients were equally assigned into the experimental group; Nano-crystalline hydroxyapatite silica gel or the negative control group;open flap debridement. Clinical and radiographic parameters were recorded at baseline and at 3 and 6 months postoperatively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 35 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Severe chronic periodontitis patients.
- •having at least one site with pocket depth ≥ 6 mm and clinical attachment level ≥ 5 mm, with radiographic evidence of bone loss as detected in periapical radiographs.
排除标准
- •Pregnant women
- •Subjects had <22 permanent teeth
- •Having any given systemic disease
- •Taking any type of medication and/or antibiotic therapy during the 3 months before the study
- •Received periodontal treatment within the past 12 months Current or former smokers
结局指标
主要结局
Clinical attachment level
时间窗: change from Baseline at 6 months
Change from baseline in clinical attachment level in mm in chronic periodontitis patients at 6 month
次要结局
- bone defect area(Baseline and 6 months)
- pocket depth(Baseline and 6 months)
研究者
Noha Ayman Ghallab
Associate Professor of Oral Medicine and Periodontology
Cairo University