NCT02843906
Unknown
Not Applicable
Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection?
University Hospital, Grenoble1 site in 1 country180 target enrollmentJuly 2015
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Senile Plaques
- Sponsor
- University Hospital, Grenoble
- Enrollment
- 180
- Locations
- 1
- Primary Endpoint
- Functionnal/Cognitive evaluation
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose of this study is to identify association between cerebrospinal fluid Alzheimer's Disease's neurodegenerescence biomarkers (tau, ptau, Aß40 and Aß1-42) and occurrence of cognitive deficits in older patients with bipolar disorders.
Investigators
Eligibility Criteria
Inclusion Criteria
- •male or female subject aged between 60 and 80 years old
- •in patient or out-patient at one of the centers participating in the study
- •Mini-mental state examination (MMSE) score \> 20 at baseline
- •patient with diagnostic of amnestic-Mild Cognitive Impairment
- •patients suffering of bipolar disorders type I or II
- •in remitted (euthymic) state at baseline
Exclusion Criteria
- •pre-existing history of dementia
- •history of neurologic disorder
- •lifetime history of a severe psychiatric disorder other than bipolar disorders
- •current medical problems
- •patients treated with electroconvulsive therapy within the past six months
- •patients with substance abuse or dependence within the past 12 months
- •patients hospitalized without consent
Outcomes
Primary Outcomes
Functionnal/Cognitive evaluation
Time Frame: Half an hour
Global cognitive evaluation : MMSE (Mini-Mental State Examination), CDR, BREF, 5 word of Dubois ADL, IADL.
Psychatric evaluation
Time Frame: 15 minutes
Scales for thymus evaluation : GDS, YMRS, BPRS, STAI
Brain MRI
Time Frame: 40 minutes
Enable neuropsychological evaluation.
Study Sites (1)
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