Hypoxia, Lung Function and Diffusion Capacity After Abdominal Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lung Function
- Sponsor
- Umeå University
- Enrollment
- 59
- Locations
- 1
- Primary Endpoint
- Diffusion capacity for carbon monoxide (DLCO)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.
Inclusion: Patients undergoing surgery for abdominal surgery
Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies.
Investigation: The day before surgery and the day after surgery
Primary outcome measures:
- Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide.
- PaO2, PaCO2 and oxygen saturation (blood gas)
Detailed Description
Postoperative hypoxia complicates 30% - 50% of abdominal surgeries. People at particular risk for postoperative pulmonary complications including severe hypoxia are those who undergo abdominal surgery, emergency surgery or have a respiratory failure due to chronic lung disease including obstructive sleep apnea. The cause of postoperative restrictive lung function and hypoxia is unknown. Previous studies report that PaO2 decreases by an average of 2 kPa after abdominal surgery, while PaCO2 is unchanged and vital capacity decreases by 35%. The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery. Design: Prospective cohort study Inclusion: Patients undergoing surgery for abdominal surgery Exclusion: Dementia or cognitive impairment that makes it impossible to participate in studies. Method: The day before surgery and the day after surgery: Lung function (Vital capacity and FEV1) using box and diffusion capacity measurements and blood gas measurement Primary outcome measures: * Pulmonary function test with dynamic spirometry (Vital capacity, FEV1) and diffusion capacity for carbon monoxide. * PaO2, PaCO2 and oxygen saturation (blood gas) Other variables examined: age, sex, height, weight, type of surgery, type of anesthesia, smoking status, length of surgery, previously known lung disease.
Investigators
Karl A Franklin
Professor
Umeå University
Eligibility Criteria
Inclusion Criteria
- •Adult patients (18 years old and older) scheduled for surgery in the abdomen at department of Surgery, Urology and Gynecologi, Umeå University hospital.
- •Must be able to perform a lung function test
Exclusion Criteria
- •Dementia or severe cognitive impairment
Outcomes
Primary Outcomes
Diffusion capacity for carbon monoxide (DLCO)
Time Frame: Change from baseline (the day before surgery) to postoperative day 1 or 2
Change in DLCO
Secondary Outcomes
- Arterial PO2(Change from baseline (the day before surgery) to postoperative day 1 or 2)
- Vital capacity (VC)(Change from baseline (the day before surgery) to postoperative day 1 or 2)
- Arterial PCO2(Change from baseline (the day before surgery) to postoperative day 1 or 2)
- Forced expiratory volume (FEV1)(Change from baseline (the day before surgery) to postoperative day 1 or 2)