Determination of the Triglyceride-distribution per CETP in the post prandial situatio

Not Applicable

• Conditions: healthy volunteers

• Registration Number: DRKS00024609
• Lead Sponsor: niversitätsklinikum FreiburgInstitut für klinische Chemie und Laboratoriumsmedizin

Brief Summary

Based on data of 12 subjects, our model was capable to estimate the CETP-mediated TG flux in postprandial lipemia. TG net flux to LDL and HDL nearly doubles in postprandial lipemia. However only HDL’s TG concentration increases significantly. The proportion of ApoC-III redistributed from HDL to VLDL is highly correlated with the change of ApoA1 in HDL2b and with the change of the ratio VLDL surface/HDL surface. Separating CM from VLDL and using both fractions instead of just using a single combined fraction <1.006 g/ml, did only improve the model’s prediction to a small degree.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-16
• Study Completion: 2022-01-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Age = 18
Written consent
Triglycerides < 150 mg/dl and Cholesterol < 200 mg/dl

Exclusion Criteria

severe liver impairment
severe renal impairment
TSH not normal
other severe intrinsic diseases
pregnancy

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
et-Flux of TG in LDL and HDL before and after a fatty meal estimated by our mathematical model and by a biochemical measurement

Secondary Outcome Measures

Name	Time	Method
Measurement of chylomicron-concentration and composition before and after fat meal. Measurement of HDL-functionality