The impact Of Neural Mobilization And Topical Magnesium On Anxiety, Depression, Sleep Quality And Functional Activities Of Daily Living In Middle Aged Adults With Cervical Radiculopathy: A Randomized Controlled Trial
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- 1. Upper limb tension test (ULTT): is a clinical assessment used to evaluate neural tension or irritation in the upper extremity. It involves a series of movements to stretch the nerves of the arm and assess symptoms like pain, tingling, or numbness, which may indicate nerve involvement. The test is often used to diagnose conditions such as cervical radiculopathy or carpal tunnel syndrome. In this there are 4 test ULTT1, ULTT2A, ULTT2B and ULTT3 out these if 3 of 4 comes positive then we can rule out cervical radiculopathy.
研究概览
简要总结
Cervical radiculopathy (CR) is a debilitating illness that adversely affects a person’s ability to function physically, mentally, and socially. The complicated presentation of cervical radiculopathy (CR) is linked to a greater reliance on healthcare services. An objective loss of sensory and/or motor function resulting from a conduction impairment to a spinal nerve or its root is known as CR. This can happen with or without discomfort. . Radiculopathy-related pain is referred to as painful radiculopathy, and if there are documented poor sensory symptoms, it may meet the criteria for definitive neuropathic pain. Magnesium works as an analgesic by inhibiting the postsynaptic N-methyl-d-aspartate (NMDA) receptors spinal neurons in the dorsal horn of the spinal cord. The physiological blockage of the calcium channels of the NMDA receptor can be restored by magnesium delivery. Magnesium treatment is thought to have an antinociceptive effect by using this process to reduce central sensitization, wind-up, and diminish dorsal horn neuron activity A randomized controlled trial study aim to analyze the effect of neural mobilization and topical magnesium on anxiety, depression, sleep quality and functional activities of daily living on cervical radiculopathy among middle age adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 30.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •Cervical radiculopathy: Persistent symptoms for at least 3 months.
- •Positive ULTT (Upper limb tension test) No allergic reaction to patch test.
排除标准
- •Individuals with severe cardiovascular disorders, renal impairment, Diabetes type II or other medical conditions where magnesium supplementation may pose a risk.
- •Participants with known allergies or sensitivities to magnesium or any components of the transdermal lotion.
- •Individuals currently taking medications or supplements that may interact with magnesium, affecting its absorption or efficacy.
- •Pregnant or lactating individuals due to potential risks to the developing fetus or nursing infant.
- •Any history of recent trauma or surgery before the study initiation.
结局指标
主要结局
1. Upper limb tension test (ULTT): is a clinical assessment used to evaluate neural tension or irritation in the upper extremity. It involves a series of movements to stretch the nerves of the arm and assess symptoms like pain, tingling, or numbness, which may indicate nerve involvement. The test is often used to diagnose conditions such as cervical radiculopathy or carpal tunnel syndrome. In this there are 4 test ULTT1, ULTT2A, ULTT2B and ULTT3 out these if 3 of 4 comes positive then we can rule out cervical radiculopathy.
时间窗: Baseline, 3 weeks and follow up after 6 months
2. Neck Disability Index (NDI): its measure the impact of cervical radiculopathy. Scores range from 0 to 5 for each of the 10 items. The top score is 50. A percentage score can be created by multiplying the acquired score by two. On rare occasions, a respondent will omit to answer a particular question. The average of all other items is then added to the completed items.
时间窗: Baseline, 3 weeks and follow up after 6 months
次要结局
- Depression, Anxiety and Stress Scale - 21 Items (DASS-21), 2. Pittsburgh Sleep Quality Index (PSQI), Cervical Radiculopathy Impact Scale (CRIS)(Baseline, 3 weeks and follow up after 6 months)
研究者
Jyoti Sharma
Galgotias University