Serum fibrinogen and fibrin degradation products (FDP) changes in hypothermia and normothermia in patients undergoing bypass
Not Applicable
- Conditions
- coronary heart disease.Atherosclerotic heart disease of native coronary artery
- Registration Number
- IRCT20180930041189N1
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
All adult patients undergoing heart surgery
Patients between 25 and 85 years
Exclusion Criteria
History of thrombosis
bleeding
regular aspirin use in the past 5 days
congenital fibrinogen disorders
liver disease
disorders or coagulation deficiencies
genetic disorders such as hemophilia
chronic renal failure patients
people with substance abuse
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The amount of fibrinogen consumed and the production of fibrinogen degradation products. Timepoint: At the beginning of the study (before the intervention) and during the bypass in two intervals after the intervention. Method of measurement: Fibrinogen using the clauss and FDP method with serology (kit ELISA).
- Secondary Outcome Measures
Name Time Method Postoperative bleeding. Timepoint: 24 hours after entering ICU. Method of measurement: Measuring Chest tube bleeding.