Implementing Physical Activity Guidelines for Adults With MS

Not Applicable

Completed

• Conditions: Multiple Sclerosis
• Interventions: Other: Direct Referral to physical activity

• Registration Number: NCT02100020
• Lead Sponsor: McMaster University

Brief Summary

The proposed project will evaluate two methods of implementation of the new Physical Activity Guidelines (PAGs) for Adults with Multiple Sclerosis (MS) living in two Ontario communities. The investigators will also determine if following the PAGs will improve aspects of fitness, function, quality of life and risk for cardiometabolic disease in this population. The investigators hypothesize that adherence to the PAGs will be higher in people who have been referred directly to a community-based exercise program, and that this greater adherence to physical activity will be associated with greater improvements in fitness, function and quality of life.

This randomized controlled trial will provide important information on how best to implement physical activity recommendations within the community setting; this information will be translated to key stakeholders during the final stages of the project.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2014-03-24
• Study First Submitted QC: 2014-03-26
• Study First Posted: 2014-03-31
• Study Start: 2014-05
• Primary Completion: 2018-03-31
• Study Completion: 2018-03-31
• Status Verified: 2018-05
• Last Update Submitted: 2018-05-29
• Last Update Posted: 2018-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

• Diagnosis of MS with mild-moderate disability (EDSS 1-7)
• Aged 18-60
• Medical clearance to participate in physical activity

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Exclusion Criteria

• current participation in regular physical activity (at least twice-weekly)
• other serious medical condition that might impair ability to participate in strength or aerobic exercise

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Direct Referral to Physical Activity	Direct Referral to physical activity	The REF group will be referred to a centre-based community exercise program in their respective community (either the MacWheelers or Revved Up) by a clinical neurologist where they will be prescribed exercise based on the PAGs for adults with MS, and according to their individual capabilities.

Primary Outcome Measures

Name	Time	Method
Adherence to the Physical Activity Guidelines	3 years	Adherence to the physical activity guidelines will be analyzed by having participants fill in a weekly physical activity log that will be sent to them by email.

Secondary Outcome Measures

Name	Time	Method
Physical Fitness	At baseline and after the 16 week intervention	Peak oxygen uptake, maximum muscle strength, bodyweight
Fatigue	At baseline and after the 16 week intervention	Multiple Sclerosis Fatigue Impact Scale (MSFIS)
Blood markers of cardiovascular disease risk	At baseline and after the 16 week intervention	blood lipid panel, HbA1c, fasting glucose
Perceived Quality of Life	At baseline and after the 16 week intervention	Multiple Sclerosis Quality of Life (MSQoL) scale
Mobility	At baseline and after the 16 week intervention	25ft walk test

Trial Locations

Locations (2)

McMaster University, Physical Activity Centre for Excellence; 🇨🇦 Hamilton, Ontario, Canada

Queens University; 🇨🇦 Kingston, Ontario, Canada