Comparison of Nutritional Status and Sarcopenia Between Children and Adolescents With Primary Ciliary Dyskinesia and Healthy Children
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Hand Grip Strength
研究概览
简要总结
To date, the literature has not yet elucidated the status of malnutrition and sarcopenia in children and adolescents with PCD compared to healthy controls. Therefore, the aim of this study is to compare the nutritional and sarcopenia status of children and adolescents with primary ciliary dyskinesia to that of healthy controls.
详细描述
Primary ciliary dyskinesia (PCD) is an autosomal recessive disorder characterized by abnormal ciliary motility and impaired mucociliary clearance, caused by mutations in the genes responsible for ciliary movement. Structural or functional defects of the cilia lead to chronic upper and lower respiratory tract infections, fertility issues, and organ asymmetry. Activities of daily living predominantly consist of movements requiring short-term and repetitive anaerobic performance, and in children particularly, physical activities generally involve brief, low-to-moderate intensity exertion. However, in children with PCD, factors such as pulmonary dysfunction, malnutrition, and decreased physical activity levels can adversely affect anaerobic exercise capacity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •for Children and Adolescents with Primary Ciliary Dyskinesia:
- •To be between the ages of 6-18
- •To have been diagnosed with primary ciliary dyskinesia
- •To be clinically stable for at least 3 weeks
- •To have the necessary cooperation for the measurements
- •To volunteer to participate in the study
- •Inclusion Criteria for Healthy Children and Adolescents:
- •To be between the ages of 6-18
- •To be in a similar average and ratio with the group of children and adolescents with primary ciliary dyskinesia in terms of age and gender
- •To have the necessary cooperation for the measurements
- •To volunteer to participate in the study
排除标准
- •for Children and Adolescents with Primary Ciliary Dyskinesia:
- •Having any orthopedic, neurological, psychological or cardiovascular problem that may prevent the measurements from being performed in the last 6 months
- •Smoking or quitting smoking
- •Exclusion Criteria for Healthy Children and Adolescents:
- •Having any orthopedic, neurological, psychological or cardiovascular problem that may prevent the measurements from being performed in the last 6 months
- •Having any chronic disease
- •Smoking or quitting smoking
结局指标
主要结局
Hand Grip Strength
时间窗: through study completion, an average of 1 year
Handgrip strength (kg) will be assessed twice in each hand using a dynamometer (Jamar) with a maximal isometric contraction lasting approximately 2 seconds. The best result (kg) will be used for data analysis.
次要结局
- Vertical Jump Power(through study completion, an average of 1 year)
- Core muscle strength(through study completion, an average of 1 year)
- Waist circumference measurement(through study completion, an average of 1 year)
- Malnutrition Risk Score of participants(through study completion, an average of 1 year)
- Body Fat Percentage(through study completion, an average of 1 year)
- Forced Vital Capacity(through study completion, an average of 1 year)
- Forced Expiratory Volume in 1 second(through study completion, an average of 1 year)
- Forced Expiratory Volume in 1 second Forced Vital Capacity Ratio(through study completion, an average of 1 year)
- Peak Expiratory Flow(through study completion, an average of 1 year)
- Forced Expiratory Flow at 25-75%(through study completion, an average of 1 year)
- Hip circumference measurement(through study completion, an average of 1 year)
- upper middle arm circumference measurement(through study completion, an average of 1 year)
- Triceps skinfold thickness(through study completion, an average of 1 year)
研究者
Gulsah Bargi
Principal Investigator
Izmir Democracy University