NCT01025024
Completed
Not Applicable
Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients Patients, A Single-nucleotide Polymorphism(SNP)Analysis for Primary Open Angle Glaucoma
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Single-nucleotide Polymorphism (SNP) for Glaucoma
- Sponsor
- Chungnam National University
- Enrollment
- 1224
- Locations
- 1
- Primary Endpoint
- genotyping for the SNP associated with primary open angle glaucoma
- Status
- Completed
- Last Updated
- 16 years ago
Overview
Brief Summary
A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.
Detailed Description
Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of primary open angle glaucoma
Exclusion Criteria
- •Primary open angle glaucoma combined with congenital ocular disease
- •Primary open angel glaucoma combined with other ocular disease
- •Significant systemic disease other than systemic hypertension and diabetes
Outcomes
Primary Outcomes
genotyping for the SNP associated with primary open angle glaucoma
Time Frame: one year
Secondary Outcomes
- genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns(one year)
Study Sites (1)
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