Investigation of Genetic Disease Marker Associated With Korean Glaucoma Patients
Completed
- Conditions
- Single-nucleotide Polymorphism (SNP) for Glaucoma
- Registration Number
- NCT01025024
- Lead Sponsor
- Chungnam National University
- Brief Summary
A single-nucleotide polymorphism (SNP) analysis of DNA obtained from peripheral blood of the glaucoma patients and the normal control will be performed to find genetic marker for primary open angle glaucoma.
- Detailed Description
Unrelated Korean subjects who have primary open angle glaucoma were recruited in the current study. Genotyping for various SNP associated with POAG due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with primary open angle glaucoma and normal control subjects free of any eye diseases.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1224
Inclusion Criteria
- Clinical diagnosis of primary open angle glaucoma
Exclusion Criteria
- Primary open angle glaucoma combined with congenital ocular disease
- Primary open angel glaucoma combined with other ocular disease
- Significant systemic disease other than systemic hypertension and diabetes
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method genotyping for the SNP associated with primary open angle glaucoma one year
- Secondary Outcome Measures
Name Time Method genotyping for rs7961953 and additional SNPs in TMTC2 from other linkage disequilibrium patterns one year
Trial Locations
- Locations (1)
Chungnam National University Hospital
🇰🇷Daejeon, Korea, Republic of
Chungnam National University Hospital🇰🇷Daejeon, Korea, Republic of