Ultrasound-guided Peripheral Nerve Block for Non-intubated Uniportal Video-assisted Thoracoscopic Surgery
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- Numerical rating scale intraoperatively
研究概览
简要总结
Traditionally, video-assisted thoracic surgery is performed under general anesthesia with double-lumen endotracheal tube. However, the complications associated with this large tube as well as inhalation anesthetics are frequently reported. Therefore, currently there is a trend toward non-intubated anesthesia methods for video-assisted thoracic surgery, which includes thoracic epidural block, peripheral nerve block, local anesthesia, local combined with peripheral nerve block, etc. Thoracic epidural block demands a high technique, but still risks catastrophic neurological complications in case of accidental dural puncture. Local anesthesia, perhaps more straightforward, however may need supplemental analgesia during incision, which will inevitably interrupt surgery and negatively affect the patients. This study aims to apply ultrasound guidance during local anesthetic injection for local anesthesia-based video assisted thoracic surgery, which helps inject the local anesthetic into the key intercostal nerve plane to provide more specific and precise blockade, thus avoiding the chance of blind injection. At the same time, ultrasound guidance has the potential to reduce the risk of systemic toxicity, prolong the duration of analgesia postoperatively, and facilitates postoperative recovery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 79 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults younger than 80 years old and weighing between 50-90 kg are scheduled for one-port video assisted thoracic surgery .
排除标准
- •Anticipated difficult airway
- •Obvious coagulation abnormality
- •Psychiatric patients or drug addiction
- •Emergency operation or patients with a full stomach
- •Difficulty in language expression
- •Allergic to local anesthetic, morphine, or NSAID
- •BMI > 35
- •Pregnancy
- •Respiratory insufficiency
- •Severe pleural adhesion
- •Need for pleurodesis
- •Refuse patient-controlled analgesia
- •Patients with a pacemaker
- •Severe liver dysfunction (serum albumin<25g/l or Child-Pugh score≧10)
- •Severe kidney dysfunction (creatinine clearance<30ml/min)
- •Inflammatory bowel disease
- •Congestive heart failure (NYHA II-IV)
- •Confirmed ischemic heart disease, peripheral arterial disease and/or cerebral vascular disease
- •Patients with a high intra-ocular pressure (e.g. glaucoma)
- •Neurological symptoms over the ipsilateral upper part of the body
研究组 & 干预措施
VATS block (ropivacaine + epinephrine)
VATS block is the peripheral nerve block for video-assisted thoracic surgery, whose injection is administered at the site of chest wall incision.
干预措施: VATS (Procedure)
VATS block (ropivacaine + epinephrine)
VATS block is the peripheral nerve block for video-assisted thoracic surgery, whose injection is administered at the site of chest wall incision.
干预措施: Ropivacaine (Drug)
VATS block (ropivacaine + epinephrine)
VATS block is the peripheral nerve block for video-assisted thoracic surgery, whose injection is administered at the site of chest wall incision.
干预措施: Epinephrine (Drug)
结局指标
主要结局
Numerical rating scale intraoperatively
时间窗: During chest wall incision
Self-reporting pain intensity, pain site, and analgesic dosage during surgery
TIme to lose skin sensation (light touch and thermal) over the injection site
时间窗: Up to 30 mins after ropivacaine injection
Skin sensation will be tested every 5 minutes after ropivacaine injection until loss of both sensation (readiness for skin incision)
次要结局
- Common characteristics of ultrasound anatomy by analyzing video clips(Three time points (upon obtaining informed consent, prior to injection and during injection))
- Ropivacaine concentration at different time points after injection(Up to 120 mins following injection)
- Numerical rating scale postoperatively(Up to 72 hours following surgery)
