Zinc Absorption From Biofortified Rice

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Other: Zinc biofortified rice; Other: Rice extrinsically fortified with zinc

• Registration Number: NCT01633450
• Lead Sponsor: Swiss Federal Institute of Technology

Brief Summary

One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops. The aim of this study is to evaluate zinc absorption from a rice biofortified with zinc when compared with a control rice fortified with zinc just before consumption.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-06
• Study First Submitted: 2012-06-29
• Study First Submitted QC: 2012-06-29
• Study First Posted: 2012-07-04
• Primary Completion: 2012-08
• Study Completion: 2012-10
• Status Verified: 2013-06
• Last Update Submitted: 2013-06-06
• Last Update Posted: 2013-06-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Male or female of 18 to 45 years old
• Body Mass Index in the range of 19 to 25
• No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion Criteria

• Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
• Long-term medication during the whole study (except for contraceptives)
• Pregnancy
• Lactation
• Intention to become pregnant during the course of the study
• Lack of safe contraception
• Consumption of mineral and vitamin supplements within 2 weeks prior to 1st - Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Zinc biofortified rice	Zinc biofortified rice	-
Rice extrinsically fortified with zinc	Rice extrinsically fortified with zinc	-

Primary Outcome Measures

Name	Time	Method
Fractional absorption of zinc	33 days	Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.

Trial Locations

Locations (1)

ETH Zurich; 🇨🇭 Zurich, Switzerland