Bioavailability of Zinc From Rice Biofortified With 70Zn and Rice Extrinsically Labeled With 70Zn in Young Adults: a Randomized, Single-blind Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 1
- 主要终点
- Fractional absorption of zinc
研究概览
简要总结
One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops. The aim of this study is to evaluate zinc absorption from a rice biofortified with zinc when compared with a control rice fortified with zinc just before consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female of 18 to 45 years old
- •Body Mass Index in the range of 19 to 25
- •No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study
排除标准
- •Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
- •Long-term medication during the whole study (except for contraceptives)
- •Pregnancy
- •Lactation
- •Intention to become pregnant during the course of the study
- •Lack of safe contraception
- •Consumption of mineral and vitamin supplements within 2 weeks prior to 1st - Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study
结局指标
主要结局
Fractional absorption of zinc
时间窗: 33 days
Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.
次要结局
未报告次要终点
研究者
Prof. Michael B. Zimmermann
Prof
Swiss Federal Institute of Technology