Bioavailability of Zinc From Rice Biofortified With 70Zn and Rice Extrinsically Labeled With 70Zn in Young Adults: a Randomized, Single-blind Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Fractional absorption of zinc
Study Overview
Brief Summary
One of the newest strategies to combat micronutrient deficiencies is the biofortification of staple foods, where higher levels of minerals are obtained through breeding of staple crops. The aim of this study is to evaluate zinc absorption from a rice biofortified with zinc when compared with a control rice fortified with zinc just before consumption.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Male or female of 18 to 45 years old
- •Body Mass Index in the range of 19 to 25
- •No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study
Exclusion Criteria
- •Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)
- •Long-term medication during the whole study (except for contraceptives)
- •Pregnancy
- •Lactation
- •Intention to become pregnant during the course of the study
- •Lack of safe contraception
- •Consumption of mineral and vitamin supplements within 2 weeks prior to 1st - Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study
Arms & Interventions
Zinc biofortified rice
Intervention: Zinc biofortified rice (Other)
Rice extrinsically fortified with zinc
Intervention: Rice extrinsically fortified with zinc (Other)
Outcomes
Primary Outcomes
Fractional absorption of zinc
Time Frame: 33 days
Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.
Secondary Outcomes
No secondary outcomes reported
Investigators
Prof. Michael B. Zimmermann
Prof
Swiss Federal Institute of Technology