Can ginger ameliorate chemotherapy-induced nausea? A double blind, randomised placebo controlled feasibility study.

Phase 2

Completed

• Conditions: Cancer - Any cancer; Chemotherapy-induced nausea and vomiting; Diet and Nutrition - Other diet and nutrition disorders; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12613000120774
• Lead Sponsor: The University of Queensland

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-01-31
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 77

Inclusion Criteria

* Chemotherapy-naive cancer patients receiving treatment of any emetogenicity.
( Previously experienced CINV symptoms in >=1 chemotherapy cycle.
* >18 years .
* Life expectancy >3 months.
* Baseline Karnofsky > 60.
* No concurrent neoplasms or illness inducing nausea independent of chemotherapy
* No self-prescribed therapies for nausea.
* Receiving moderate or highly emetogenic chemotherapy treatment.
* Receiving 5HT3 antagonist.

Exclusion Criteria

The following exclusion criteria will apply:
* Patients requiring radiotherapy.
* Pregnant or lactating.
* Concurrent use of other ginger-containing supplements and ingestion of large quantities of ginger.
* History of adverse reactions to ginger.
* Patients with malignancies of gastrointestinal tract/gastrointestinal diseases or nausea and vomiting due to reasons other than chemotherapy.
* Thrombocytopenia or patients undergoing chemotherapy that is likely to cause thrombocyopenia (<50 x 10^9/L).
* Currently prescribed warfarin or on anti-coagulant therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified