Effect of Indication Based Blood Product Transfusion in Patients Undergoing Major Oncological Surgery
- Conditions
- Blood Transfusion
- Interventions
- Procedure: blood volume loss based blood transfusionProcedure: hemoglobin concentration based blood transfusion
- Registration Number
- NCT05607940
- Lead Sponsor
- Second Affiliated Hospital, School of Medicine, Zhejiang University
- Brief Summary
Investigators aimed to compare the effect on different indications (blood volume loss based VS hemoglobin concentration based ) based blood transfusion practices in patients undergoing major oncological surgery for pelvic or spinal tumor and investigate their postoperative complications.
- Detailed Description
260 patients underwent major oncological surgery for open pelvic or spinal tumor resection were included in this study. We looked at white blood cells, hemoglobin, hematocrit, neutrophil ratio, C-reactive protein, erythrocyte sedimentation rate, and IL-6 levels 1 day, 3 days, and 7 days after surgery The main question it sought to answer was whether there was a difference in postoperative complications 30 days after surgery between patients who received blood transfusions based on volume loss and those who received blood transfusions based on hemoglobin concentration during surgery.
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 260
- age between 18 and 70
- patients with pelvic or spinal tumor
- conduct open resection surgery for tumor removal
- with expected surgery duration greater than 3 hours
- with expected blood loss greater than 400 ml
- age < 18 or >70
- Limb tumor patients or patients with pelvic and spinal tumors undergoing closed internal fixation or vertebroplasty or minimally invasive surgery
- received chemotherapy or immunotherapy before surgery
- with expected surgery length less than 3 hours
- with expected intraoperative blood loss less than 400ml
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description blood volume loss based blood transfusion blood volume loss based blood transfusion intraoperative blood transfusion begin once blood volume loss over 400ml hemoglobin concentration based blood transfusion hemoglobin concentration based blood transfusion intraoperative blood transfusion begin once hemoglobin concentration below 70g/L
- Primary Outcome Measures
Name Time Method percentage of the postoperative complication patients were carefully followed for complication occurrence 1 month after surgery. Major postoperative complications include but are not limited to surgical site infection, lung infection, deep vein thrombosis, pressure ulcers and so on
- Secondary Outcome Measures
Name Time Method transfusion of red packed blood cells during hospitalization after surgery, an averagy of 1 week total volume of blood transfusion calculated after surgery
length of hospital stay during hospitalization after surgery, an averagy of 1 week Number of days patients stay in hospital after surgery.
neutrophil ratio 1 day，3 days，7 days，and 30 days after surgery the neutrophil ratio was measured in patients 1 day, 3 days, and 7 days and 30 days after surgery.
hemoglobin level 1 day，3 days，7 days，and 30 days after surgery hemoglobin level was measured in patients 1 day, 3 days, and 7 days and 30 days after surgery.
C-reactive protein 1 day，3 days，7 days，and 30 days after surgery C-reactive protein was measured in patients 1 day, 3 days, and 7 days and 30 days after surgery.
White blood cell count 1 day，3 days，7 days，and 30 days after surgery White blood cell count was measured in patients 1 day, 3 days, and 7 days and 30 days after surgery.
hematocrit 1 day，3 days，7 days，and 30 days after surgery hematocrit was measured in patients 1 day, 3 days, and 7 days and 30 days after surgery.
erythrocyte sedimentation rate 1 day，3 days，7 days，and 30 days after surgery erythrocyte sedimentation rate was measured in patients 1 day, 3 days, and 7 days and 30 days after surgery.
nterleukin-6 level 1 day，3 days，7 days，and 30 days after surgery Interleukin-6 level was measured in patients 1 day, 3 days, and 7 days and 30 days after surgery.