Medium-term Effects of Molecular Hydrogen on Metabolic Fitness in Obesity
Phase 3
Completed
- Conditions
- Obesity
- Interventions
- Dietary Supplement: PlaceboDietary Supplement: Molecular hydrogen
- Registration Number
- NCT02832219
- Lead Sponsor
- Center for Health, Exercise and Sport Sciences, Serbia
- Brief Summary
Molecular hydrogen (H2) effectively tackles obesity-related disorders in animal models yet no studies so far investigated the effectiveness of H2 for improving biomarkers of obesity in humans. In this double blind, placebo-controlled, crossover pilot trial, the investigators will evaluate the effects of H2 intervention on body composition, hormonal status, and mitochondrial function in middle age overweight women, with hydrogen administered orally for 4 weeks.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 12
Inclusion Criteria
- age > 55 years
- body mass index > 25 kg/m2
Exclusion Criteria
- no history of H2 supplementation within the 4 weeks before study commenced
- no major chronic diseases, as evaluated by pre-participation health screening and clinical chemistry
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Placebo Cellulose, tablet, 2 g/day, 4 weeks Molecular hydrogen Molecular hydrogen Molecular hydrogen, tablet, 2 g/day, 4 weeks
- Primary Outcome Measures
Name Time Method Body fat percentage change Baseline vs. four weeks Baseline vs. four weeks
- Secondary Outcome Measures
Name Time Method Serum insulin change in IU/mL Baseline vs. four weeks Baseline vs. four weeks
Trial Locations
- Locations (1)
Center for Health, Exercise and Sport Sciences
🇷🇸Belgrade, Serbia